Rasburicase (trade names Elitek in the US and Fasturtec in the EU) is a medication that helps to clear uric acid from the blood. It is a recombinant version of urate oxidase, an enzyme that metabolizes uric acid to allantoin. Urate oxidase is known to be present in many mammals but does not naturally occur in humans.[2] Rasburicase is produced by a genetically modified Saccharomyces cerevisiae strain. The complementary DNA (cDNA) coding for rasburicase was cloned from a strain of Aspergillus flavus.[2]
Rasburicase (Q00511) is a tetrameric protein with identical subunits. Each subunit is made up of a single 301 amino acid polypeptide chain with a molecular mass of about 34 kDa. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek (rasburicase) is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.[3]
It is on the World Health Organization's List of Essential Medicines.[4]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ abWilson FP, Berns JS (October 2012). "Onco-nephrology: tumor lysis syndrome". Clinical Journal of the American Society of Nephrology. 7 (10): 1730–1739. doi:10.2215/CJN.03150312. PMID 22879434.
^"Elitek (rasburicase)". Rxlist.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Rasburicase (trade names Elitek in the US and Fasturtec in the EU) is a medication that helps to clear uric acid from the blood. It is a recombinant version...
Pegloticase is a PEGylated recombinant porcine-like uricase. Similarly to rasburicase, it metabolises uric acid to allantoin. This reduces the risk of urate...
during TLS, and this can be accomplished with use of allopurinol or rasburicase. Allopurinol (a xanthine oxidase inhibitor, which inhibits uric acid...
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risk of developing gout. Urate oxidase is formulated as a protein drug (rasburicase) for the treatment of acute hyperuricemia in patients receiving chemotherapy...
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production of uric acid: xanthine oxidase inhibitors, urate oxidase (rasburicase), and sevelamer. Hypouricemia is common in vegetarians and vegans due...
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