ROS1 information

ROS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZBF, 4UXL
Identifiers
Aliases	ROS1, MCF3, ROS, c-ros-1, ROS proto-oncogene 1, receptor tyrosine kinase
External IDs	OMIM: 165020; MGI: 97999; HomoloGene: 2207; GeneCards: ROS1; OMA:ROS1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	117,425,942 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	52,071,340 bp
RNA expression pattern
	Top expressed in
	upper lobe of left lung; ; corpus epididymis; ; right lung; ; lower lobe of lung; ; testicle; ; muscle of thigh; ; visceral pleura; ; decidua; ; caput epididymis; ; Brodmann area 9;
	Top expressed in
	semen; ; epithelium of small intestine; ; ileum; ; duodenum; ; precursor cell; ; lumbar subsegment of spinal cord; ; migratory enteric neural crest cell; ; spermatid; ; submandibular gland; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; protein phosphatase binding; ATP binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; cell surface; perinuclear region of cytoplasm; cytoplasm; integral component of plasma membrane; receptor complex;
Biological process	cell differentiation; regulation of TOR signaling; signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of phosphate transport; negative regulation of gene expression; protein phosphorylation; spermatogenesis; regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine autophosphorylation; cell population proliferation; columnar/cuboidal epithelial cell development; regulation of cell growth; negative regulation of signal transduction; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	6098
	19886
	ENSG00000047936
	ENSMUSG00000019893
	P08922
	Q78DX7
	NM_002944; NM_001378891; NM_001378902
	NM_011282
	NP_002935; NP_001365820; NP_001365831
	NP_035412
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000047936 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019893 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Galland F, Stefanova M, Lafage M, Birnbaum D (July 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
^ "Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000047936 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019893 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1611909-5] Galland F, Stefanova M, Lafage M, Birnbaum D (July 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.

[entrez-6] "Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)".

ROS1 information

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ROS1

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Receptor tyrosine kinase

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Metabotropic receptor

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