RIC8A information

RIC8A
Identifiers
Aliases	RIC8A, RIC8, RIC8 guanine nucleotide exchange factor A
External IDs	OMIM: 609146 MGI: 2141866 HomoloGene: 23331 GeneCards: RIC8A
Gene location (Human)
Chr.	Chromosome 11 (human)
End	215,113 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,444,285 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; smooth muscle tissue; ; gallbladder; ; anterior pituitary; ; prefrontal cortex; ; right coronary artery; ; left uterine tube; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	Paneth cell; ; aortic valve; ; supraoptic nucleus; ; external carotid artery; ; fossa; ; ascending aorta; ; internal carotid artery; ; condyle; ; conjunctival fornix; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; G-protein alpha-subunit binding;
Cellular component	cytoplasm; plasma membrane; membrane;
Biological process	visual learning; G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; cell migration involved in gastrulation; cell-cell adhesion involved in gastrulation; vasculature development; in utero embryonic development; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; gastrulation; response to light stimulus; basement membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	60626
	101489
	ENSG00000177963
	ENSMUSG00000025485
	Q9NPQ8
	Q3TIR3
	NM_001286134; NM_021932; NM_001386941; NM_001386942
	NM_053194
	NP_001273063; NP_068751
	NP_444424
	Wikidata
View/Edit Human	View/Edit Mouse

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177963 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025485 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMC 4704990. PMID 10985349.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177963 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025485 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10985349-5] Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMC 4704990. PMID 10985349.

[pmid11230166-6] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-7] "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".

RIC8A information

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RIC8A

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ADCY5