adenylate cyclase-modulating G protein-coupled receptor signaling pathway
human ageing
dopamine receptor signaling pathway
response to morphine
positive regulation of GTPase activity
response to organonitrogen compound
negative regulation of calcium ion transport
forebrain development
neuron projection development
response to hydrogen peroxide
cellular process
signal transduction
protein folding
Wnt signaling pathway, calcium modulating pathway
odontogenesis of dentin-containing tooth
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2775
14681
Ensembl
ENSG00000087258
ENSMUSG00000031748
UniProt
P09471 Q8N6I9
P18872
RefSeq (mRNA)
NM_020988 NM_138736
NM_001113384 NM_010308
RefSeq (protein)
NP_066268 NP_620073 NP_066268.1 NP_620073.2
NP_001106855 NP_034438
Location (UCSC)
Chr 16: 56.19 – 56.36 Mb
Chr 8: 94.54 – 94.7 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene.[5][6][7]
Mutations in this gene have been shown to cause epileptic encephalopathy.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000087258 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031748 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Murtagh JJ Jr; Eddy R; Shows TB; Moss J; Vaughan M (Mar 1991). "Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16". Mol Cell Biol. 11 (2): 1146–55. doi:10.1128/MCB.11.2.1146. PMC 359797. PMID 1899283.
^Kinoshita M, Nukada T, Asano T, Mori Y, Akaike A, Satoh M, Kaneko S (Jul 2001). "Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels". J Biol Chem. 276 (31): 28731–8. doi:10.1074/jbc.M104806200. PMID 11395521.
^Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, Terashima H, Osaka H, Nakamura S, Tohyama J, Kumada T, Furukawa T, Iwata S, Shiihara T, Kubota M, Miyatake S, Koshimizu E, Nishiyama K, Nakashima M, Tsurusaki Y, Miyake N, Hayasaka K, Ogata K, Fukuda A, Matsumoto N, Saitsu H (September 2013). "De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy". Am. J. Hum. Genet. 93 (3): 496–505. doi:10.1016/j.ajhg.2013.07.014. PMC 3769919. PMID 23993195.
in humans is encoded by the GNAO1 gene. Mutations in this gene have been shown to cause epileptic encephalopathy. GNAO1 has been shown to interact with:...
gene GNAI2. Gi3α is encoded by the gene GNAI3. Go1α is encoded by the gene GNAO1. Gzα is encoded by the gene GNAZ. Transducin/Gt1α is encoded by the gene...
proteins that have differential expression in individuals with schizophrenia (GNAO1). Due to the prevalence of synesthesia among the first-degree relatives...
proteins by acting as GTPase activators. RGS5 has been shown to interact with GNAO1, GNAI2 and GNAI3. GRCh38: Ensembl release 89: ENSG00000143248 – Ensembl...
Galpha i/Galpha q-linked signaling. RGS19 has been shown to interact with GNAO1, GIPC1, OSTM1, GNAI1, GNAI3 and GNAZ. GRCh38: Ensembl release 89: ENSG00000171700...
humans is encoded by the RIC8A gene. RIC8A has been shown to interact with GNAO1, GNA13, GNAQ, GNAS complex locus, GNAI2, GNAI1 and GNAI3. GRCh38: Ensembl...
expression may be regulated by MITF. RGS20 has been shown to interact with GNAO1 and GNAZ. GRCh38: Ensembl release 89: ENSG00000147509 – Ensembl, May 2017...
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