RGS12 information

RGS12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBZ, 2KV8
Identifiers
Aliases	RGS12, regulator of G protein signaling 12
External IDs	OMIM: 602512; MGI: 1918979; HomoloGene: 2195; GeneCards: RGS12; OMA:RGS12 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	3,439,913 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	35,196,988 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right uterine tube; ; skin of abdomen; ; prefrontal cortex; ; cingulate gyrus; ; vagina; ; right lobe of liver; ; nucleus accumbens; ; gastric mucosa; ; putamen;
	Top expressed in
	spermatocyte; ; lip; ; hand; ; spermatid; ; ganglionic eminence; ; esophagus; ; atrium; ; olfactory bulb; ; superior frontal gyrus; ; otolith organ;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase regulator activity; GTPase activator activity; GTPase activity;
Cellular component	cytoplasm; cell projection; nuclear matrix; synapse; condensed nuclear chromosome; cell junction; dendrite; plasma membrane; nucleus; nucleolus; cytosol;
Biological process	regulation of G protein-coupled receptor signaling pathway; transcription, DNA-templated; positive regulation of GTPase activity; negative regulation of signal transduction; signal transduction; regulation of catalytic activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6002
	71729
	ENSG00000159788
	ENSMUSG00000029101
	O14924
	Q8CGE9
NM_002926; NM_198227; NM_198229; NM_198230; NM_198430;
	NM_198432; NM_198587; NM_001394154; NM_001394155; NM_001394156; NM_001394157; NM_001394158; NM_001394159; NM_001394161; NM_001394162; NM_001394163
	NM_001163512; NM_173402
	NP_002917; NP_937870; NP_937872
NP_001156984; NP_775578; NP_001390400; NP_001390401; NP_001390402;
	NP_001390403; NP_001390404; NP_001390405; NP_001390406; NP_001390407
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.^[5]^[6]

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159788 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029101 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
^ ^a ^b "Entrez Gene: RGS12 regulator of G-protein signalling 12".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159788 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029101 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9651375-5] Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.

[entrez-6] "Entrez Gene: RGS12 regulator of G-protein signalling 12".

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