negative regulation of myeloid cell differentiation
spleen development
negative regulation of transcription, DNA-templated
positive regulation of transcription of Notch receptor target
regulation of alternative mRNA splicing, via spliceosome
RNA methylation
dosage compensation by inactivation of X chromosome
thrombopoietin-mediated signaling pathway
regulation of megakaryocyte differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
64783
229700
Ensembl
ENSG00000162775
ENSMUSG00000048109
UniProt
Q96T37
Q0VBL3
RefSeq (mRNA)
NM_001201545 NM_022768 NM_014092
NM_001045807
RefSeq (protein)
NP_001188474 NP_073605
NP_001039272
Location (UCSC)
Chr 1: 110.34 – 110.35 Mb
Chr 3: 107.23 – 107.24 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene.[5][6][7]
It is an RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m6A) methylation of RNAs[8]
^ abcGRCh38: Ensembl release 89: ENSG00000162775 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000048109 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet. 28 (3): 220–1. doi:10.1038/90054. PMID 11431691. S2CID 36236342.
^Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA (May 2001). "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia". Proc Natl Acad Sci U S A. 98 (10): 5776–9. Bibcode:2001PNAS...98.5776M. doi:10.1073/pnas.101001498. PMC 33289. PMID 11344311.
^"Entrez Gene: RBM15 RNA binding motif protein 15".
^"UniProtKB - Q96T37 (RBM15_HUMAN)". Retrieved 29 October 2018.
Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene. It is an RNA-binding protein that acts as a key regulator of N6-Methyladenosine...
with translocations between chromosome 1 and 22 – [t(1;22)(p13.3;q13.1);] RBM15-MKL1; AML with mutated NPM1 AML with biallelic mutations of CEBPA Provisional:...
3;q26.2); GATA2, MECOM AML (megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1 AML with BCR-ABL1 AML with mutated NPM1 AML with biallelic mutation...
translocation involves the RBM15 gene on chromosome 1 and the MKL1 gene (also termed MRTFA) on chromosome 22 to create a RBM15-MKL1 fusion gene. Studies...
domain containing 1B". Retrieved 2018-01-13. Lee JH, Skalnik DG (2012). "Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC...
using WTAP. After a METTL3-METTL14-WTAP complex forms, METTL3 can bind to RBM15. Then, MTC can be recruited at specific sites in the RNA. METTL3 acts as...
recruitment of mRNA, whereas RBM15 and its paralog RBM15B are only involved in the recruitment of lncRNAs. The role RBM15 and RBM15B may have in recruiting...
transferase-like 3 (METTL3) and its cofactors like METTL14, WTP, KIAA1492 and RBM15/RBM15B which adds the m6A modification in the nucleus. The family of proteins...
M, Herbrick JA, Cui X, et al. (July 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nature...
Grijzenhout A, Pintacuda G, et al. (July 2015). "A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing". Cell...
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