MKL1 information

MRTFA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KVU, 2KW9
Identifiers
Aliases	MRTFA, BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, MKL1, myocardin related transcription factor A
External IDs	OMIM: 606078; MGI: 2384495; HomoloGene: 32487; GeneCards: MRTFA; OMA:MRTFA - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	40,636,719 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,074,958 bp
RNA expression pattern
	Top expressed in
	monocyte; ; popliteal artery; ; bone marrow cells; ; blood; ; stromal cell of endometrium; ; left uterine tube; ; sural nerve; ; canal of the cervix; ; left coronary artery; ; thymus;
	Top expressed in
	olfactory tubercle; ; blood; ; internal carotid artery; ; molar; ; subiculum; ; external carotid artery; ; knee joint; ; entorhinal cortex; ; superior frontal gyrus; ; nucleus accumbens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; actin monomer binding; leucine zipper domain binding; protein binding; actin binding;
Cellular component	cytoplasm; nucleoplasm; nucleus; cytosol;
Biological process	regulation of transcription, DNA-templated; smooth muscle cell differentiation; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	57591
	223701
	ENSG00000196588
	ENSMUSG00000042292
	Q969V6
	Q8K4J6
	NM_001282660; NM_001282661; NM_001282662; NM_020831; NM_001318139
	NM_001082536; NM_153049
	NP_001269589; NP_001269590; NP_001269591; NP_001305068; NP_065882
	NP_001076005; NP_694629
	Wikidata
View/Edit Human	View/Edit Mouse

MKL/megakaryoblastic leukemia 1 (also termed MRTFA/myocardin related transcription factor A) is a protein that in humans is encoded by the MKL1 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196588 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042292 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, et al. (July 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nature Genetics. 28 (3): 220–221. doi:10.1038/90054. PMID 11431691. S2CID 36236342.
^ Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, et al. (August 2002). "Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death". The Journal of Biological Chemistry. 277 (32): 28853–28860. doi:10.1074/jbc.M203190200. PMID 12019265.
^ Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS (April 2004). "Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells". The Journal of Biological Chemistry. 279 (17): 17578–17586. doi:10.1074/jbc.M400961200. PMID 14970199.
^ "Entrez Gene: MKL1 megakaryoblastic leukemia (translocation) 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196588 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042292 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11431691-5] Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, et al. (July 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nature Genetics. 28 (3): 220–221. doi:10.1038/90054. PMID 11431691. S2CID 36236342.

[pmid12019265-6] Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, et al. (August 2002). "Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death". The Journal of Biological Chemistry. 277 (32): 28853–28860. doi:10.1074/jbc.M203190200. PMID 12019265.

[pmid14970199-7] Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS (April 2004). "Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells". The Journal of Biological Chemistry. 279 (17): 17578–17586. doi:10.1074/jbc.M400961200. PMID 14970199.

[entrez-8] "Entrez Gene: MKL1 megakaryoblastic leukemia (translocation) 1".

MKL1 information

and 21 Related for: MKL1 information

MKL1

Miscarriage

Down syndrome

Birth defect

Acute myeloid leukemia

Turner syndrome

Tumors of the hematopoietic and lymphoid tissues

Chromosome 22

Acute megakaryoblastic leukemia

Tumor necrosis factor

Breast development

Miscarriage risks

Miscarriage and mental disorders

RBM15

22q13 deletion syndrome

Set domain containing 1b

List of primary immunodeficiencies

MKL2

Polysomy

Serum response factor

Paracanoeing at the 2016 Summer Paralympics