regulation of signal transduction by p53 class mediator
DNA repair
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5810
19355
Ensembl
ENSG00000113456
ENSMUSG00000022248
UniProt
O60671
Q9QWZ1
RefSeq (mRNA)
NM_001033673 NM_002853 NM_133282 NM_133377
NM_001289447 NM_001289448 NM_011232
RefSeq (protein)
NP_002844
NP_001276376 NP_001276377 NP_035362
Location (UCSC)
Chr 5: 34.91 – 34.92 Mb
Chr 15: 10.49 – 10.5 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000113456 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022248 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Freire R, Murguía JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP (September 1998). "Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis". Genes Dev. 12 (16): 2560–73. doi:10.1101/gad.12.16.2560. PMC 317084. PMID 9716408.
^Bluyssen HA, van Os RI, Naus NC, Jaspers I, Hoeijmakers JH, de Klein A (January 1999). "A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene". Genomics. 54 (2): 331–7. doi:10.1006/geno.1998.5582. PMID 9828137.
Testis-specific disruption of RAD1 in mice results in defective double-strand break repair, depletion of germ cells and infertility. RAD1homolog has been shown to...
RAD1 can refer to: Nintendo Research & Development 1 RAD1homolog, a human gene This disambiguation page lists articles associated with the same title...
non-homologous flaps of the 3' overhangs are cut away by a set of nucleases, known as Rad1/Rad10, which are brought to the flaps by the Saw1 and Slx4 proteins. New...
proteins are localized to a valid site of DNA replication stress. The RAD9-HUS1-Rad1 (9-1-1) heterotrimeric clamp and its clamp loader RFCRad17 are able to recognize...
In eukaryotes, a homologous, heterotrimeric "9-1-1 clamp" made up of RAD9-RAD1-HUS1 (911) is responsible for DNA damage checkpoint control. This 9-1-1 clamp...
Sørensen CS, Syljuåsen RG, Lukas J, Bartek J (2006). "ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage". Cell...
repair, TOPBP1 was found to associate with Rad9, which forms a complex with Rad1 and Hus1, hereby termed the 9-1-1 DNA repair clamp. TOPBP1 binds to Rad9...
complex. In budding yeast, Rad2 and the Rad1-Rad10 complex make the 5' and 3' cuts, respectively. In mammals, the homologs XPG and XPF-ERCC1 affect the same...
"The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". The Journal of Biological Chemistry. 275 (38): 29767–71...
other eukaryotic genomes. Some of the most studied gene orthologs include RAD1 in the budding yeast Saccharomyces cerevisiae, and rad16+ in the fission...