RAB3A information

RAB3A
Identifiers
Aliases	RAB3A, member RAS oncogene family
External IDs	OMIM: 179490; MGI: 97843; HomoloGene: 20629; GeneCards: RAB3A; OMA:RAB3A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,204,042 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,211,323 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; Brodmann area 9; ; prefrontal cortex; ; nucleus accumbens; ; amygdala; ; putamen; ; hypothalamus; ; cingulate gyrus; ; spinal ganglia;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; central gray substance of midbrain; ; subiculum; ; dorsomedial hypothalamic nucleus; ; prefrontal cortex; ; habenula; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase binding; GTP binding; myosin V binding; protein C-terminus binding; protein binding; ATPase activator activity; GTP-dependent protein binding; GTPase activity; GDP-dissociation inhibitor binding;
Cellular component	extracellular vesicle; endosome; clathrin-sculpted monoamine transport vesicle membrane; membrane; synaptic vesicle; plasma membrane; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; clathrin-sculpted acetylcholine transport vesicle membrane; axon; terminal bouton; acrosomal vesicle; intracellular organelle; clathrin-sculpted glutamate transport vesicle membrane; cytosol; secretory granule membrane; anchored component of synaptic vesicle membrane; vesicle; protein-containing complex; presynaptic active zone; secretory granule; perinuclear region of cytoplasm;
Biological process	respiratory system process; positive regulation of ATP-dependent activity; axonogenesis; lung development; synaptic vesicle exocytosis; regulation of short-term neuronal synaptic plasticity; evoked neurotransmitter secretion; mitochondrion organization; response to electrical stimulus; post-embryonic development; constitutive secretory pathway; maintenance of presynaptic active zone structure; glutamate secretion; regulation of exocytosis; regulation of synaptic vesicle fusion to presynaptic active zone membrane; neuromuscular synaptic transmission; synaptic vesicle recycling; sensory perception of touch; protein transport; positive regulation of exocytosis; synaptic vesicle maturation; neurotransmitter secretion; positive regulation of regulated secretory pathway; exocytosis; neutrophil degranulation; post-translational protein modification; transport; intracellular protein transport; vesicle docking involved in exocytosis; protein secretion; Rab protein signal transduction; protein localization to plasma membrane; plasma membrane repair; regulation of synaptic vesicle priming; synaptic vesicle transport; acrosomal vesicle exocytosis; regulation of synaptic vesicle exocytosis; calcium-ion regulated exocytosis; synaptic vesicle clustering;
	Sources:Amigo / QuickGO
Orthologs
	5864
	19339
	ENSG00000105649
	ENSMUSG00000031840
	P20336
	P63011
	NM_002866
	NM_001166399; NM_009001; NM_001328047; NM_001378892; NM_001378893
	NP_002857; NP_002857.1
	NP_001159871; NP_001314976; NP_033027; NP_001365821; NP_001365822
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene.^[5]^[6]^[7] It is involved in calcium-triggered exocytosis in neurons.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105649 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031840 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rousseau-Merck MF, Zahraoui A, Bernheim A, Touchot N, Miglierina R, Tavitian A, Berger R (January 1990). "Chromosome mapping of the human ras-related rab3A gene to 19p13.2". Genomics. 5 (4): 694–8. doi:10.1016/0888-7543(89)90110-9. PMID 2687157.
^ Brondyk WH, McKiernan CJ, Fortner KA, Stabila P, Holz RW, Macara IG (March 1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A". Mol Cell Biol. 15 (3): 1137–43. doi:10.1128/MCB.15.3.1137. PMC 230335. PMID 7532276.
^ "Entrez Gene: RAB3A RAB3A, member RAS oncogene family".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105649 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031840 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2687157-5] Rousseau-Merck MF, Zahraoui A, Bernheim A, Touchot N, Miglierina R, Tavitian A, Berger R (January 1990). "Chromosome mapping of the human ras-related rab3A gene to 19p13.2". Genomics. 5 (4): 694–8. doi:10.1016/0888-7543(89)90110-9. PMID 2687157.

[pmid7532276-6] Brondyk WH, McKiernan CJ, Fortner KA, Stabila P, Holz RW, Macara IG (March 1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A". Mol Cell Biol. 15 (3): 1137–43. doi:10.1128/MCB.15.3.1137. PMC 230335. PMID 7532276.

[entrez-7] "Entrez Gene: RAB3A RAB3A, member RAS oncogene family".

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