This article is about rational protein design. For the broader engineering of proteins, see Protein engineering.
Protein design is the rational design of new protein molecules to design novel activity, behavior, or purpose, and to advance basic understanding of protein function.[1] Proteins can be designed from scratch (de novo design) or by making calculated variants of a known protein structure and its sequence (termed protein redesign). Rational protein design approaches make protein-sequence predictions that will fold to specific structures. These predicted sequences can then be validated experimentally through methods such as peptide synthesis, site-directed mutagenesis, or artificial gene synthesis.
Rational protein design dates back to the mid-1970s.[2] Recently, however, there were numerous examples of successful rational design of water-soluble and even transmembrane peptides and proteins, in part due to a better understanding of different factors contributing to protein structure stability and development of better computational methods.
^Korendovych, Ivan (March 19, 2018). "Minimalist design of peptide and protein catalysts". American Chemical Society. Retrieved March 22, 2018.
^Richardson, JS; Richardson, DC (July 1989). "The de novo design of protein structures". Trends in Biochemical Sciences. 14 (7): 304–9. doi:10.1016/0968-0004(89)90070-4. PMID 2672455.
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