Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous retinal detachment. PVR occurs in about 8–10% of patients undergoing primary retinal detachment surgery and prevents the successful surgical repair of rhegmatogenous retinal detachment. PVR can be treated with surgery to reattach the detached retina but the visual outcome of the surgery is very poor.[1][2] A number of studies have explored various possible adjunctive agents for the prevention and treatment of PVR, such as methotrexate, although none have yet been licensed for clinical use.[3]
PVR was originally referred to as massive vitreous retraction and then as massive periretinal proliferation. The name proliferative vitreo retinopathy was provided in 1989 by the Silicone Oil Study group. The name is derived from proliferation (by the retinal pigment epithelial and glial cells) and vitreo retinopathy to include the tissues which are affected, namely the vitreous humor (or simply vitreous) and the retina.[4]
^
Leaver PK (1995). "Proliferative vitreoretinopathy". British Journal of Ophthalmology. 79 (10): 871–872. doi:10.1136/bjo.79.10.871. PMC 505283. PMID 7488570.
^"Proliferative Vitreoretinopathy". Retina and Vitreous of Texas. Archived from the original on 2004-05-06. Retrieved 2009-05-28.
^Balas, Michael; Abdelaal, Ahmed; Popovic, Marko M.; Kertes, Peter J.; Muni, Rajeev H. (2022-10-01). "Intravitreal Methotrexate for the Prevention and Treatment of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment: A Systematic Review". Ophthalmic Surgery, Lasers and Imaging Retina. 53 (10): 561–568. doi:10.3928/23258160-20220920-04. ISSN 2325-8160. PMID 36239680. S2CID 252896329.
^Ceron OM, Arroyo JG (2009). "Better Outcomes May Be Ahead for PVR". Review of Ophthalmology. 16: 1. Retrieved 2009-05-29.[permanent dead link]
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