Prokaryotic messenger RNA (mRNA) degradation, also called prokaryotic mRNA decay,[1] is an important part of gene regulation in prokaryotes..[2] In this process, specific proteins target and break down mRNA. These proteins break down certain sections of the mRNA, such as 5’ ends and specific base pairs.[2] This degradation happens in response to different environmental cues, allowing the organism to stop expressing certain genes in order to survive. This also occurs during and after translation, in order to reuse the material that was used to create the RNA. This process can vary, depending on the organism and the situation.[2]
mRNA degradation targets specific sequences of messenger RNA, allowing some to stay in the cell for longer than others—and even genes within the same strand of RNA can be degraded at different rates. This is true in both prokaryotes and eukaryotes. Because of this, mRNA degradation plays a key role in determining which genes are expressed. Also, this process gives organisms greater evolutionary fitness, as it means they do not have to expend energy to find new resources.[2]
^Kushner, Sidney R. (October 2004). "mRNA Decay in Prokaryotes and Eukaryotes: Different Approaches to a Similar Problem". IUBMB Life. 56 (10): 585–594. doi:10.1080/15216540400022441. PMID 15814456.
^ abcdHui, Monica P.; Foley, Patricia L.; Belasco, Joel G. (2014). "Messenger RNA Degradation in Bacterial Cells". Annual Review of Genetics. 48: 537–559. doi:10.1146/annurev-genet-120213-092340. PMC 4431577. PMID 25292357.
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