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Postreplication checkpoint information


A postreplication checkpoint is a DNA damage checkpoint response that provides time for the repair of daughter-strand gaps generated by the eukaryotic replication fork at sites of DNA damage.[1]

  1. ^ Callegari AJ, Kelly TJ (October 2006). "UV irradiation induces a postreplication DNA damage checkpoint". Proceedings of the National Academy of Sciences of the United States of America. 103 (43): 15877–82. doi:10.1073/pnas.0607343103. PMC 1613229. PMID 17043220.

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Postreplication checkpoint

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A postreplication checkpoint is a DNA damage checkpoint response that provides time for the repair of daughter-strand gaps generated by the eukaryotic...

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Checkpoint

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logistics Cell cycle checkpoint, control mechanisms in eukaryotic cell division G1 restriction point S postreplication checkpoint, prevents cell cycle...

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Cell cycle checkpoint

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DNA damage checkpoint Postreplication checkpoint Meiotic recombination checkpoint Hartwell, L.; Weinert, T. (3 November 1989). "Checkpoints: controls that...

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Postreplication repair

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Postreplication repair is the repair of damage to the DNA that takes place after replication. Some example genes in humans include: BRCA2 and BRCA1 BLM...

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Cell division

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purpose for this checkpoint is to check for appropriate cell size and any DNA damage . The second check point is in the G2 phase, this checkpoint also checks...

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Cell cycle

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cellular checkpoints. An alternative model of the cell cycle response to DNA damage has also been proposed, known as the postreplication checkpoint. Checkpoint...

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MAD2L2

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checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene. MAD2L2 is a component of the mitotic spindle assembly checkpoint that...

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DNA repair

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multiple genes responsible for postreplication repair, homologous recombination, nucleotide excision repair, DNA damage checkpoint, global transcriptional activation...

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Poland syndrome

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CM, Fishel R, Takahashi M (2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38):...

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BRCA1

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Abraham RT (December 2000). "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress". Genes Dev. 14 (23): 2989–3002. doi:10...

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REV3L

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R, Takahashi M (September 2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38):...

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RAD18

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Yamaizumi M (July 2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proceedings of the...

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UBE2V2

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Venere M, Scolnick DM, Halazonetis TD (October 2003). "The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains"...

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UBE2N

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family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. UBE2N has been shown to interact with: AURKA, HLTF, TRAF2,...

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MSH2

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R (January 2003). "The mismatch repair system is required for S-phase checkpoint activation". Nat. Genet. 33 (1): 80–4. doi:10.1038/ng1052. PMID 12447371...

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