UBE2N information

UBE2N
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J7D, 2C2V, 3HCT, 3HCU, 3VON, 3W31, 4DHI, 4DHJ, 4DHZ, 4IP3, 4NR3, 4NRG, 4NRI, 4ONL, 4ONM, 4ONN, 4ORH, 4TKP, 5AIT, 5AIU, 4WHV
Identifiers
Aliases	UBE2N, HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13, ubiquitin conjugating enzyme E2 N, UBCHBEN
External IDs	OMIM: 603679; MGI: 1934835; HomoloGene: 128406; GeneCards: UBE2N; OMA:UBE2N - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	93,441,947 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	95,381,519 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; ganglionic eminence; ; islet of Langerhans; ; ventricular zone; ; right ventricle; ; pons; ; human penis; ; myocardium;
	Top expressed in
	spermatid; ; spermatocyte; ; ventricular zone; ; tail of embryo; ; esophagus; ; embryo; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; blastocyst; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ubiquitin protein ligase activity; ubiquitin binding; protein binding; ATP binding; ubiquitin protein ligase binding; RNA binding; ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity;
Cellular component	cytoplasm; cytosol; UBC13-UEV1A complex; ubiquitin ligase complex; nucleoplasm; extracellular exosome; UBC13-MMS2 complex; nucleus; fibrillar center; protein-containing complex;
Biological process	postreplication repair; protein K63-linked ubiquitination; regulation of DNA repair; DNA double-strand break processing; positive regulation of DNA repair; stimulatory C-type lectin receptor signaling pathway; proteolysis; cellular response to DNA damage stimulus; Fc-epsilon receptor signaling pathway; global genome nucleotide-excision repair; positive regulation of histone modification; positive regulation of ubiquitin-protein transferase activity; protein ubiquitination; regulation of histone ubiquitination; positive regulation of I-kappaB kinase/NF-kappaB signaling; T cell receptor signaling pathway; double-strand break repair via nonhomologous end joining; nucleotide-binding oligomerization domain containing signaling pathway; histone ubiquitination; DNA repair; double-strand break repair via homologous recombination; JNK cascade; positive regulation of NF-kappaB transcription factor activity; ubiquitin-dependent protein catabolic process; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7334
	93765
	ENSG00000177889
	ENSMUSG00000074781
	P61088
	P61089
	NM_003348
	NM_080560
	NP_003339
	NP_542127
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177889 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074781 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamaguchi T, Kim NS, Sekine S, Seino H, Osaka F, Yamao F, Kato S (February 1997). "Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product". J Biochem. 120 (3): 494–97. doi:10.1093/oxfordjournals.jbchem.a021440. PMID 8902611.
^ "Entrez Gene: UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177889 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074781 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8902611-5] Yamaguchi T, Kim NS, Sekine S, Seino H, Osaka F, Yamao F, Kato S (February 1997). "Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product". J Biochem. 120 (3): 494–97. doi:10.1093/oxfordjournals.jbchem.a021440. PMID 8902611.

[entrez-6] "Entrez Gene: UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)".

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