In enzymology, a polyphosphate kinase (EC 2.7.4.1), or polyphosphate polymerase, is an enzyme that catalyzes the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate moieties.[1]
ATP + (phosphate)n ADP + (phosphate)n+1
Thus, the two substrates of this enzyme are ATP and polyphosphate [(phosphate)n], whereas its two products are ADP and polyphosphate extended by one phosphate moiety [(phosphate)n+1].
This enzyme is a membrane protein and goes through an intermediate stage during the reaction where it is autophosphorylated with a phosphate group covalently linked to a basic amino acyl residue through an N-P bond.
Several enzymes catalyze polyphosphate polymerization. Some of these enzymes couple phosphotransfer to transmembrane transport. These enzyme/transporters are categorized in the Transporter Classification Database (TCDB) under the Polyphosphate Polymerase/YidH Superfamily (TC# 4.E.1) and are transferases that transfer phosphoryl groups (phosphotransferases) with polyphosphate as the acceptor. The systematic name of this enzyme class is ATP:polyphosphate phosphotransferase. This enzyme is also called polyphosphoric acid kinase.
^Brown MR, Kornberg A (June 2008). "The long and short of it - polyphosphate, PPK and bacterial survival". Trends Biochem. Sci. 33 (6): 284–90. doi:10.1016/j.tibs.2008.04.005. PMID 18487048.
and 18 Related for: Polyphosphate kinase information
enzymology, a polyphosphatekinase (EC 2.7.4.1), or polyphosphate polymerase, is an enzyme that catalyzes the formation of polyphosphate from ATP, with...
Inositol polyphosphatekinase (IPK) is a family of enzymes that have a similar 3-dimensional structure. All members of the family catalyze the transfer...
in 1993 and is part of the polyphosphate operon along with polyphosphatekinase, the enzyme which synthesizes polyphosphate. The Kornberg lab was very...
out research on DNA replication and polyphosphate synthesis. She discovered and characterized polyphosphatekinase (PPK), an enzyme that helps build long...
Tsutsumi K, Ishige K, Noguchi T (March 2000). "Inorganic polyphosphate and polyphosphatekinase: their novel biological functions and applications". Biochemistry...
strains is based purely of molecular biology techniques. To date, the polyphosphatekinase (ppk1) and the PHA synthase (phaC) genes have been used to characterise...
proportion of ATP3−. Polyanionic and featuring a potentially chelating polyphosphate group, ATP binds metal cations with high affinity. The binding constant...
Joyoti; Kundu, Manikuntala (1 December 2009). "Polyphosphatekinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria". Molecular Microbiology...
Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple...
Caldwell KK, et al. (1999). "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol". Proc. Natl...
ITPKA belongs to the inositol polyphosphatekinase (IPK) family. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating...
phase include Rnr (RNase R) and the putative RNA helicase HrpA. Ppk (polyphosphatekinase) is another constituent that has been reported to be part of the...
Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene. INPP4B encodes the inositol polyphosphate 4-phosphatase...
pentakisphosphate by a newly identified family of higher inositol polyphosphatekinases". Curr Biol. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X....
pentakisphosphate by a newly identified family of higher inositol polyphosphatekinases". Curr. Biol. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X...
protein 2 FASTKD1: FAST kinase domain-containing protein 1 IMP4: U3 small nucleolar ribonucleoprotein INPP1: Inositol polyphosphate 1-phosphatase INPP4A:...