Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.[5]
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, a dual specificity phosphatase. INPP4B is involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate and phosphate groups from phosphotyrosines.[6] There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000109452 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037940 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: Inositol polyphosphate-4-phosphatase, type II, 105kDa". Retrieved 2012-07-24.
^Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU (October 2013). "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research Communications. 440 (2): 277–82. doi:10.1016/j.bbrc.2013.09.077. PMC 4578723. PMID 24070612.
is encoded by the INPP4B gene. INPP4B encodes the inositol polyphosphate 4-phosphatase type II, a dual specificity phosphatase. INPP4B is involved in phosphatidylinositol...