Plasmapheresis (from the Greek πλάσμα, plasma, something molded, and ἀφαίρεσις aphairesis, taking away) is the removal, treatment, and return or exchange of blood plasma or components thereof from and to the blood circulation. It is thus an extracorporeal therapy, a medical procedure performed outside the body.[citation needed]
Three general types of plasmapheresis can be distinguished:
Autologuous, removing blood plasma, treating it in some way, and returning it to the same person, as a therapy.
Exchange, a patient's blood plasma is removed, while blood products are given in replacement. This type is called plasma exchange (PE, PLEX, or PEX) or plasma exchange therapy (PET). The removed plasma is discarded and the patient receives replacement donor plasma, albumin, or a combination of albumin and saline (usually 70% albumin and 30% saline).
Donation, removing blood plasma, separating its components, and returning some of them to the same person, while holding out others to become blood products that this person donates for those in need. In such a plasma donation procedure, blood is removed from the body, blood cells and plasma are separated, and the blood cells are returned, while the plasma is collected and frozen to preserve it for eventual use as fresh frozen plasma or as an ingredient in the manufacture of blood products.[1]
Plasmapheresis of the autologous and exchange types is used to treat a variety of disorders, including those of the immune system, such as Goodpasture's syndrome,[2] Guillain–Barré syndrome, lupus, myasthenia gravis,[3][4] and thrombotic thrombocytopenic purpura.
^"Why Donate Plasma". Archived from the original on 25 November 2011. Retrieved 26 September 2011.
^MedlinePlus. "Goodpasture syndrome". U.S. National Library of Medicine. Retrieved 7 April 2013.
^Yazdi, MF; Baghianimoghadam, M; Nazmiyeh, H; Ahmadabadi, AD; Adabi, MA (2012). "Response to plasmapheresis in myasthenia gravis patients: 22 cases report". Revue roumaine de médecine interne. 50 (3): 245–47. PMID 23330293.
^Batocchi, AP; Evoli, A; Di Schino, C; Tonali, P (2000). "Therapeutic apheresis in myasthenia gravis". Therapeutic Apheresis. 4 (4): 275–79. doi:10.1046/j.1526-0968.2000.004004275.x. PMID 10975473.
Plasmapheresis (from the Greek πλάσμα, plasma, something molded, and ἀφαίρεσις aphairesis, taking away) is the removal, treatment, and return or exchange...
surgical removal of the thymus may improve symptoms in certain cases. Plasmapheresis and high-dose intravenous immunoglobulin may be used during sudden flares...
needed]There are several categories of component collections: Plasmapheresis – blood plasma. Plasmapheresis is useful in collecting FFP (fresh frozen plasma) of...
(1.025 g/ml). Blood serum is blood plasma without clotting factors. Plasmapheresis is a medical therapy that involves blood plasma extraction, treatment...
CSL Plasma is a plasmapheresis company which claims to be one of the largest companies of its kind in the world. It is a subsidiary of CSL Limited, a biotechnology...
interview, Lindner explained: "I did a blood cleanse twice .... I did plasmapheresis, which removes heavy metals and all that stuff." He had decided to undergo...
immune system such as corticosteroids and cyclophosphamide, and with plasmapheresis, in which the antibodies are removed from the blood. The disease was...
therapy; fewer than half in the United States train in the provision of plasmapheresis. Only pediatric trained physicians are able to train in pediatric nephrology...
thrombotic TTP, as it fuels the coagulopathy. Since the early 1990s, plasmapheresis has become the treatment of choice for TTP. This is an exchange transfusion...
Dr Josep A. Grifols Lucas was the first researcher to publish the plasmapheresis procedure in 1952. The company introduced its liquid IVIG product into...
and other treatments include corticosteroids (e.g., prednisone), and plasmapheresis (plasma exchange) which may be prescribed alone or in combination with...
Treatment of TTP was revolutionized in the 1980s with the application of plasmapheresis. According to the Furlan–Tsai hypothesis, this treatment works by removing...
Packed red blood cells transfusion Fresh frozen plasma transfusion Plasmapheresis of various kinds, including plasma exchange Autohemotherapy, with autologous...
IUT alone group. IVIG and plasmapheresis together can reduce or eliminate the need for an IUT. Plasmapheresis – Plasmapheresis aims to decrease the maternal...
reveals dilation of retinal veins and flame shaped retinal hemorrhages. Plasmapheresis may be used to decrease viscosity in the case of myeloma, whereas leukapheresis...
damage. Methods of treatment include intravenous immunoglobulin (IVIG), plasmapheresis, and corticosteroids. Immunoglobulin samples are obtained from a large...
attacks that do not respond to corticosteroids might be treatable by plasmapheresis. Multiple disease-modifying medications were approved by regulatory...
In more extreme cases, the use of immunosuppressive drugs and even plasmapheresis may be considered. The initial discovery of the disease is credited...
used to spread passive immunity to many diseases via blood donation (plasmapheresis). For example, convalescent serum, passive antibody transfusion from...
of modern treatments such as prednisone, intravenous immunoglobulin, plasmapheresis, chemotherapies, and other drugs, the prognosis was poor. The cutaneous...
purification, and a variety of other measures. Many equine facilities now use plasmapheresis to collect blood plasma instead of blood serum. There is an overall...
produced by the lymphoma cells causes the blood to become so thick that plasmapheresis is performed to remove the protein. Watchful waiting may be appropriate...
contraindicated as they facilitate further clot formation and RBC lysis. Plasmapheresis is one treatment for TTP; corticosteroids should also be considered...
or cyclophosphamide in combination with high-dose corticosteroids. Plasmapheresis is sometimes recommended for very severe manifestations of GPA, such...
Global Information