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Pindone information


Pindone
Names
Preferred IUPAC name
2-(2,2-Dimethylpropanoyl)-1H-indene-1,3(2H)-dione
Other names
2-Pivaloyl-1,3-indandione
Identifiers
CAS Number
  • 83-26-1 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 6476 checkY
ECHA InfoCard 100.001.330 Edit this at Wikidata
KEGG
  • C19141 ☒N
PubChem CID
  • 6732
UNII
  • 2KFI1XBH7G checkY
CompTox Dashboard (EPA)
  • DTXSID1025930 Edit this at Wikidata
InChI
  • InChI=1S/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3 checkY
    Key: RZKYEQDPDZUERB-UHFFFAOYSA-N checkY
  • InChI=1/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3
    Key: RZKYEQDPDZUERB-UHFFFAOYAX
SMILES
  • O=C2c1ccccc1C(=O)C2C(=O)C(C)(C)C
Properties
Chemical formula
C14H14O3
Molar mass 230.26 g/mol
Appearance Bright-yellow powder[1]
Odor almost none
Density 1.06 g/mL
Melting point 110 °C (230 °F; 383 K)
Solubility in water
0.002% (25°C)[1]
Hazards
Lethal dose or concentration (LD, LC):
LD50 (median dose)
280 mg/kg (rat, oral)
75 mg/kg (dog, oral)
150 mg/kg (rabbit, oral)[2]
NIOSH (US health exposure limits):
PEL (Permissible)
TWA 0.1 mg/m3[1]
REL (Recommended)
TWA 0.1 mg/m3[1]
IDLH (Immediate danger)
100 mg/m3[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Pindone is an anticoagulant drug[3] for agricultural use. It is commonly used as a rodenticide in the management of rat and rabbit populations.

It is pharmacologically analogous to warfarin and inhibits the synthesis of Vitamin K-dependent clotting factors.

  1. ^ a b c d e NIOSH Pocket Guide to Chemical Hazards. "#0516". National Institute for Occupational Safety and Health (NIOSH).
  2. ^ "Pindone". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  3. ^ Robinson MH, Twigg LE, Wheeler SH, Martin GR (March 2005). "Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries". Comp. Biochem. Physiol. B. 140 (3): 465–73. doi:10.1016/j.cbpc.2004.11.011. PMID 15694595.

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