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Chemical compound
Phenylthiocarbamide (PTC), also known as phenylthiourea (PTU), is an organosulfur thiourea containing a phenyl ring.
It has the unusual property that it either tastes very bitter or is virtually tasteless, depending on the genetic makeup of the taster. The ability to taste PTC is often treated as a dominant genetic trait, although inheritance and expression of this trait are somewhat more complex.[2][3]
PTC also inhibits melanogenesis and is used to grow transparent fish.[4]
About 70% of people can taste PTC, varying from a low of 58% for Indigenous Australians and indigenous peoples of New Guinea to 98% for indigenous peoples of the Americas.[5] One study has found that non-smokers and those not habituated to coffee or tea have a statistically higher percentage of tasting PTC than the general population.[6][7] PTC does not occur in food, but related chemicals do, and food choice can be related to a person's ability to taste PTC.[6][8]
^GHS: Record of Phenylthiourea in the GESTIS Substance Database of the Institute for Occupational Safety and Health, accessed on 2021-12-22.
^Guo; Reed, D. R. (2001). "The genetics of phenylthiocarbamide perception". Annals of Human Biology. 28 (2): 111–142. doi:10.1080/03014460151056310. PMC 3349222. PMID 11293722.
^McDonald, John H. "PTC tasting: The Myth". Myths of Human Genetics. Retrieved 11 May 2015.
^Karlsson, Johnny; von Hofsten, Jonas; Olsson, Per-Erik (2001). "Generating Transparent Zebrafish: A Refined Method to Improve Detection of Gene Expression During Embryonic Development". Marine Biotechnology. 3 (6): 522–527. doi:10.1007/s1012601-0053-4. PMID 14961324. S2CID 7980753.
^Kim U, Wooding S, Ricci D, Jorde LB, Drayna D (2005). "Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci". Human Mutation. 26 (3): 199–204. doi:10.1002/humu.20203. PMID 16086309. S2CID 31248094.
^ abFischer R, Griffin F, Kaplan AR (1963). "Taste thresholds, cigarette smoking, and food dislikes". Medicina Experimentalis. International Journal of Experimental Medicine. 9 (3): 151–67. doi:10.1159/000135346. PMID 14083335.
^Kaplan AR, Glanville EV, Fischer R (1964). "Taste thresholds for bitterness and cigarette smoking". Nature. 202 (4939): 1366. Bibcode:1964Natur.202.1366K. doi:10.1038/2021366a0. PMID 14210998. S2CID 4184237.
Phenylthiocarbamide (PTC), also known as phenylthiourea (PTU), is an organosulfur thiourea containing a phenyl ring. It has the unusual property that...
Arthur L. Fox, a chemist at DuPont, discovered that some people found phenylthiocarbamide (PTC) bitter, while others found it tasteless. Fox describes the...
result from the fact that these plants contain a compound similar to phenylthiocarbamide (PTC), which is either bitter or tasteless to people depending on...
Kell blood group (on chromosome 7 q33) and the ability to taste phenylthiocarbamide, or PTC, a bitter-tasting thiourea compound. Bitter taste receptor...
functions as a taste receptor, mediated by ligands such as PROP and phenylthiocarbamide that bind to the receptor and initiate signaling that confers various...
influence the ability to taste both 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Though it has often been proposed that varying taste receptor...
with drugs such as warfarin, and genotoxicity. People who can taste phenylthiocarbamide (PTC), which is either bitter or tasteless, are less likely to find...
ethyl 3-oxohexanoate and thiourea. Propylthiouracil, together with phenylthiocarbamide (PTC), are known to have bitter taste. However, it seems the propensity...
Arthur Fox, a chemist at DuPont, in Wilmington, Delaware, synthesized phenylthiocarbamide (PTC). Some researchers reported a bitter taste when entering his...
v t e Cruciferous biochemistry Types of compounds Phenylthiocarbamide (PTC/PTU) Thiocyanates Nitriles Indoles Gibberellin Glucosinolates Glucobrassicin...
ripe. There is an inverse correlation between the ability to taste phenylthiocarbamide and bitterness in A. bunius. The native range of wild trees of Antidesma...
and pseudogenization. Researchers use two synthetic substances, phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) to study the genetics of bitter...
abiogenesis Phase-transfer catalyst, that facilitates interphase migration Phenylthiocarbamide, an organosulfur thiourea Poly(trimethylene carbonate), a derivative...
cycloheximide, denatonium, PROP (6-n-propyl-2-thiouracil), PTC (phenylthiocarbamide), and β-glucopyranosides. Signal transduction of bitter stimuli is...
cells containing the receptors to bitter compounds, most famously phenylthiocarbamide (PTC). Exposure to PTC causes an intracellular cascade as evidenced...
bitter thiourea compounds, such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC), is genetically determined. PROP tasters tend to have more...
famous puzzle in human genetics is the genetic ability to taste phenylthiocarbamide (phenylthiourea or PTC), a morphism which was discovered in 1931...
in PTC taste perception. PTC is the bitter antithyroid compound phenylthiocarbamide, and the ability to perceive this compound is attributed to the gene...
the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide". Science. 299 (5610): 1221–1225. Bibcode:2003Sci...299.1221K. doi:10...
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