Glomerulus; note "Glomerular basement membrane and podocytes".
Scheme of filtration barrier (blood-urine) in the kidney. A. The endothelial cells of the glomerulus; 1. pore (fenestra). B. Glomerular basement membrane: 1. lamina rara interna 2. lamina densa 3. lamina rara externa
C. Podocytes: 1. enzymatic and structural protein 2. filtration slit 3. diaphragm
Identifiers
MeSH
D050533
FMA
74274
Anatomical terminology
[edit on Wikidata]
The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus. The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule.[1] The glomerular basement membrane is a fusion of the endothelial cell and podocyte basal laminas,[2] and is the main site of restriction of water flow.[3] Glomerular basement membrane is secreted and maintained by podocyte cells.
^Jarad, G.; Miner, J. H. (2009). "Update on the glomerular filtration barrier". Current Opinion in Nephrology and Hypertension. 18 (3): 226–232. doi:10.1097/mnh.0b013e3283296044. PMC 2895306. PMID 19374010.
^Nosek, Thomas M. "Section 7/7ch04/7ch04p07". Essentials of Human Physiology. Archived from the original on 2016-03-24. - "Basement Membrane"
^Lote, Christopher J. Principles of Renal Physiology, 5th edition. Springer. p. 35.
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The glomerularbasementmembrane of the kidney is the basal lamina layer of the glomerulus. The glomerular endothelial cells, the glomerularbasement membrane...
also known as anti–glomerularbasementmembrane disease, is a rare autoimmune disease in which antibodies attack the basementmembrane in lungs and kidneys...
basement membranes is the glomerularbasementmembrane of the kidney, by the fusion of the basal lamina from the endothelium of glomerular capillaries and the...
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Basilar membrane Bruch's membrane Descemet's membraneGlomerularbasementmembrane The glomerularbasementmembrane is a special case, consisting of a fusion...
the world. Thin basementmembrane disease is an autosomal dominant inherited disease characterized by thin glomerularbasementmembranes on electron microscopy...
is not known. One theory proposes that it is caused by a thin glomerularbasementmembrane and red blood cell (RBC) renal tubular congestion that leads...
collagen fibrils of the glomerularbasementmembrane. As a consequence, the collagen fibrils of the glomerularbasementmembrane are unable to form cross-links...
binding of antibodies to antigens in the glomerularbasementmembrane. The antigens may be part of the basementmembrane, or deposited from elsewhere by the...
Glomerulonephritis is characterized by inflammation and thinning of the glomerularbasementmembrane and the occurrence of small pores in the podocytes of the glomerulus...
this is always a pathological process. Glomerular causes include: IgA nephropathy Thin glomerularbasementmembrane disease Hereditary nephritis (Alport's...
enabling efficient ultrafiltration. Podocytes secrete and maintain the basementmembrane. There are numerous coated vesicles and coated pits along the basolateral...
vasculitis (CV), IgA vasculitis (Henoch-Schönlein) (IgAV), and anti-glomerularbasementmembrane (anti-GBM) disease are the categories of immune complex SVV....
of glomerulonephritis caused by deposits in the kidney glomerular mesangium and basementmembrane (GBM) thickening, activating the complement system and...
vasculitis (CV), IgA vasculitis (Henoch-Schönlein) (IgAV), and anti-glomerularbasementmembrane (anti-GBM) disease are the categories of immune complex SVV....
filaments from mesangial cells to the glomerularbasementmembrane can alter capillary flow by changing glomerular ultrafiltration surface area. Extraglomerular...
filtration barrier consists of fenestrated endothelial cells, the glomerularbasementmembrane, and the podocytes of epithelial cells. Nephrin is a transmembrane...
as circulating red blood cells) or extracellular material (such as basementmembrane). This subsequently leads to cell lysis, tissue damage or loss of...
The filtering structure (glomerular filtration barrier) has three layers composed of endothelial cells, a basementmembrane, and podocytes (foot processes)...
shows a characteristic sequence of changes from thinning of the glomerularbasementmembrane (GBM), developing into areas of thinning and thickening, and...
of the filtration slits of podocytes. Glomerular capillary endothelial cells, the glomerularbasementmembrane and the filtration slits function as the...
of development. It is a major proteoglycan component in the glomerularbasementmembrane and may play a role in the renal filtration and cell-matrix interactions...
This finding is due to immune complex deposition along the glomerularbasementmembrane, leading to a typical granular appearance in immunofluorescence...
activity, removing proteins and other molecules trapped in the glomerularbasementmembrane or filtration barrier. The Bowman's capsule has an outer parietal...
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