Pentagestrone information

Pentagestrone
Clinical data
Other names	17α-Hydroxyprogesterone 3-cyclopentyl enol ether
Drug class	Progestogen ether
Identifiers
	IUPAC name 1-[(8R,9S,10R,13S,14S,17R)-3-cyclopentyloxy-17-hydroxy-10,13-dimethyl-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]ethanone;
CAS Number	7001-56-1;
PubChem CID	3047827;
ChemSpider	2310139;
UNII	L34YL185WL;
ChEMBL	ChEMBL2104801;
Chemical and physical data
Formula	C26H38O3
Molar mass	398.587 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)C1(CCC2C1(CCC3C2CC=C4C3(CCC(=C4)OC5CCCC5)C)C)O;
	InChI InChI=1S/C26H38O3/c1-17(27)26(28)15-12-23-21-9-8-18-16-20(29-19-6-4-5-7-19)10-13-24(18,2)22(21)11-14-25(23,26)3/h8,16,19,21-23,28H,4-7,9-15H2,1-3H3/t21-,22+,23+,24+,25+,26+/m1/s1; Key:RBFQPFFCDLXWQK-UXUCURBISA-N;

Pentagestrone (INNTooltip International Nonproprietary Name), also known as 17α-hydroxyprogesterone 3-cyclopentyl enol ether, is a steroidal progestin of the 17α-hydroxyprogesterone group that was never marketed.^[1]^[2] An acetate ester, pentagestrone acetate (Gestovis, Gestovister), has been marketed for clinical use.^[1] Pentagestrone was described in the literature in 1960.^[1]

^ ^a ^b ^c Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 943–. ISBN 978-1-4757-2085-3.
^ Wermuth CG (2 May 2011). The Practice of Medicinal Chemistry. Academic Press. pp. 731–. ISBN 978-0-08-056877-5.

[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 943–. ISBN 978-1-4757-2085-3.

[Wermuth2011-2] Wermuth CG (2 May 2011). The Practice of Medicinal Chemistry. Academic Press. pp. 731–. ISBN 978-0-08-056877-5.

Pentagestrone information

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Pentagestrone

Pentagestrone acetate

List of progestogen esters

PGA

Valproate

Trenbolone acetate

C26H38O3

Dydrogesterone

Progestogen

Spironolactone

Steroid

Trenbolone

Triamcinolone acetonide

Progesterone

Mifepristone

Mometasone

Levonorgestrel

Megestrol

Transgender hormone therapy

Medroxyprogesterone acetate

Pharmacokinetics of progesterone

Ulipristal acetate