Pendrin is an anion exchange protein that in humans is encoded by the SLC26A4 gene (solute carrier family 26, member 4).[1][2]
Pendrin was initially identified as a sodium-independent chloride-iodide exchanger[3] with subsequent studies showing that it also accepts formate and bicarbonate as substrates.[4][5] Pendrin is similar to the Band 3 transport protein found in red blood cells. Pendrin is the protein which is mutated in Pendred syndrome, which is an autosomal recessive disorder characterized by sensorineural hearing loss, goiter and a partial organification problem detectable by a positive perchlorate test.[6]
Pendrin is responsible for mediating the electroneutral exchange of chloride (Cl−) for bicarbonate (HCO3−) across a plasma membrane in the chloride cells of freshwater fish.
By phylogenetic analysis, pendrin has been found to be a close relative of prestin present on the hair cells or organ of corti in the inner ear. Prestin is primarily an electromechanical transducer but pendrin is an ion transporter.
^"Entrez Gene: SLC26A4 solute carrier family 26, member 4".
^Everett LA, Glaser B, Beck JC, Idol JR, Buchs A, Heyman M, Adawi F, Hazani E, Nassir E, Baxevanis AD, Sheffield VC, Green ED (December 1997). "Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)". Nature Genetics. 17 (4): 411–22. doi:10.1038/ng1297-411. PMID 9398842. S2CID 39359838.
^Scott DA, Wang R, Kreman TM, Sheffield VC, Karniski LP (April 1999). "The Pendred syndrome gene encodes a chloride-iodide transport protein". Nature Genetics. 21 (4): 440–3. doi:10.1038/7783. PMID 10192399. S2CID 23717390.
^Scott DA, Karniski LP (January 2000). "Human pendrin expressed in Xenopus laevis oocytes mediates chloride/formate exchange". American Journal of Physiology. Cell Physiology. 278 (1): C207-11. doi:10.1152/ajpcell.2000.278.1.c207. PMID 10644529. S2CID 18841371.
^Soleimani M, Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, Burnham CE (February 2001). "Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex". American Journal of Physiology. Renal Physiology. 280 (2): F356-64. doi:10.1152/ajprenal.2001.280.2.f356. PMID 11208611.
^Patterson C, Runge MS (2006). Principles of molecular medicine. Totowa, NJ: Humana Press. p. 957. ISBN 1-58829-202-9.
Pendrin is an anion exchange protein that in humans is encoded by the SLC26A4 gene (solute carrier family 26, member 4). Pendrin was initially identified...
Kirsten M.; Nielsen, Søren (2002-10-01). "Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney". American Journal...
tubule, epithelial sodium channels, and chloride-bicarbonate exchanger pendrin. This will promote sodium reabsorption and fluid retention, causing diuretic...
side, iodide is shuttled across the apical membrane into the colloid via pendrin, after which thyroid peroxidase oxidizes iodide to atomic iodine (I) or...
then travels from within the cell into the lumen, through the action of pendrin, an iodide-chloride antiporter. In the follicular lumen, the iodide is...
attributable entirely to chloride depletion, which leads to a failure of pendrin, a chloride/bicarbonate exchanger in the collecting duct. Diagnosis of...
It has been linked to mutations in the PDS gene, which codes for the pendrin protein (solute carrier family 26, member 4, SLC26A4). The gene is located...
iodide is secreted into the colloid by the chloride/iodide transporter pendrin. Thyroid diverticulum List of human cell types derived from the germ layers...
is moved across the apical membrane into the colloid of the follicle by pendrin. Thyroperoxidase oxidizes two I− to form I2. Iodide is non-reactive, and...
Resting and IL-4-Stimulated Human Bronchial Epithelial Cells: Role of Pendrin and Anion Channels". Journal of Immunology. 178 (8): 5144–5153. doi:10...
resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels". J. Immunol. 178 (8): 5144–53. doi:10.4049/jimmunol...
caused by mutations in which compromise the function of the encoded protein pendrin - an anion Cl−/HCO3 − exchanger expressed in the inner ear. The loss of...
Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, Burnham CE (February 2001). "Pendrin: an apical Cl−/OH−/HCO3− exchanger in the kidney cortex". American Journal...
PMID 10732805. S2CID 22195848. Soleimani M, Greeley T, Petrovic S, et al. (2001). "Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex". Am. J. Physiol...
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