Cell compartment found in the nucleus's interchromatin space
An overlay of a fluorescence micrograph (green) onto a DIC image of a HeLa cell expressing a Yellow fluorescent Protein fusion of Paraspeckle Protein 1 (PSP1): 1. cytoplasm; 2. nucleus; 3. nucleolus; 4. paraspeckles
In cell biology, a paraspeckle is an irregularly shaped compartment of the cell, approximately 0.2-1 μm in size,[1] found in the nucleus' interchromatin space.[2] First documented in HeLa cells, where there are generally 10-30 per nucleus,[3] Paraspeckles are now known to also exist in all human primary cells, transformed cell lines and tissue sections.[4] Their name is derived from their distribution in the nucleus; the "para" is short for parallel and the "speckle" refers to the splicing speckles to which they are always in close proximity.[3] Their function is still not fully understood, but they are thought to regulate gene expression by sequestrating proteins or mRNAs with inverted repeats in their 3′ UTRs.[5][6]
^Fox A (2007-03-07). "Paraspeckle Size" (Interview). Interviewed by Sundby R. E-mail Correspondence.
^Fox AH, Lam YW, Leung AK, Lyon CE, Andersen J, Mann M, Lamond AI (January 2002). "Paraspeckles: a novel nuclear domain". Current Biology. 12 (1): 13–25. Bibcode:2002CBio...12...13F. doi:10.1016/S0960-9822(01)00632-7. PMID 11790299.
^ abFox A, Bickmore W (2004). "Nuclear Compartments: Paraspeckles". Archived from the original on 2 May 2006. Retrieved 6 March 2007.
^Fox AH, Bond CS, Lamond AI (November 2005). "P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner". Molecular Biology of the Cell. 16 (11): 5304–15. doi:10.1091/mbc.E05-06-0587. PMC 1266428. PMID 16148043.
^Cite error: The named reference Imamura_2014 was invoked but never defined (see the help page).
^Hirose T, Virnicchi G, Tanigawa A, Naganuma T, Li R, Kimura H, et al. (January 2014). "NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies". Molecular Biology of the Cell. 25 (1): 169–83. doi:10.1091/mbc.e13-09-0558. PMC 3873887. PMID 24173718.
In cell biology, a paraspeckle is an irregularly shaped compartment of the cell, approximately 0.2-1 μm in size, found in the nucleus' interchromatin...
karyosomal association (PIKA), promyelocytic leukaemia (PML) bodies, paraspeckles, and splicing speckles. Although little is known about a number of these...
which assists in forming the structure of nuclear structures known as paraspeckles: nuclear bodies which contain RNA-binding proteins. They control gene...
structures called paraspeckles. NEAT1 RNA interacts with a paraspeckle protein known as P54nrb or NONO and it is essential for paraspeckle formation. Some...
90%. Dual label FISH image; Bifidobacteria Cy3, Total bacteria FITC. Paraspeckles visualized by single-molecule FISH against NEAT1 (Quasar 570) in U-2...
discovered as a COUP-TFI interacting protein. In the nucleus, BCL11A forms paraspeckles that co-localize with NONO. In neurons, BCL11A interacts with CASK to...
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