NUDT21 information

NUDT21
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CL3, 2J8Q, 3BAP, 3BHO, 3MDG, 3MDI, 3N9U, 3P5T, 3P6Y, 3Q2S, 3Q2T
Identifiers
Aliases	NUDT21, CFIM25, CPSF5, nudix hydrolase 21
External IDs	OMIM: 604978 MGI: 1915469 HomoloGene: 5090 GeneCards: NUDT21
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,452,199 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	94,763,659 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; pons; ; caput epididymis; ; germinal epithelium; ; superior vestibular nucleus; ; Achilles tendon; ; endometrium; ; corpus epididymis; ; oocyte; ; trigeminal ganglion;
	Top expressed in
	superior cervical ganglion; ; spermatocyte; ; spermatid; ; yolk sac; ; hand; ; ganglionic eminence; ; habenula; ; morula; ; neural tube; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; histone deacetylase binding; protein binding; mRNA binding; hydrolase activity; RNA binding; identical protein binding; chromatin binding; mRNA 3'-UTR AU-rich region binding;
Cellular component	paraspeckles; centrosome; nucleoplasm; microtubule organizing center; mRNA cleavage factor complex; nucleus; nuclear body; cytoplasm; mRNA cleavage and polyadenylation specificity factor complex;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; protein tetramerization; mRNA 3'-end processing; mRNA polyadenylation; mRNA processing; posttranscriptional regulation of gene expression; cell differentiation; positive regulation of mRNA cleavage; protein heterotetramerization; pre-mRNA cleavage required for polyadenylation; mRNA alternative polyadenylation; positive regulation of mRNA polyadenylation; messenger ribonucleoprotein complex assembly; positive regulation of stem cell differentiation; positive regulation of pro-B cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	11051
	68219
	ENSG00000167005
	ENSMUSG00000031754
	O43809
	Q9CQF3
	NM_007006
	NM_026623
	NP_008937
	NP_080899
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an enzyme that in humans is encoded by the NUDT21 gene.^[5]^[6] It belongs to the Nudix family of hydrolases.

The protein encoded by this gene is one subunit of the cleavage factor Im complex required for 3' RNA cleavage and polyadenylation processing.^[7] The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167005 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031754 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ruegsegger U, Blank D, Keller W (Jul 1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits". Mol Cell. 1 (2): 243–53. doi:10.1016/S1097-2765(00)80025-8. PMID 9659921.
^ ^a ^b "Entrez Gene: NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21".
^ Hardy, J. G.; Norbury, C. J. (15 August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–1057. doi:10.1042/BST20160078. PMID 27528751. S2CID 206156045.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167005 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031754 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9659921-5] Ruegsegger U, Blank D, Keller W (Jul 1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits". Mol Cell. 1 (2): 243–53. doi:10.1016/S1097-2765(00)80025-8. PMID 9659921.

[entrez-6] "Entrez Gene: NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21".

[Hardy-7] Hardy, J. G.; Norbury, C. J. (15 August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–1057. doi:10.1042/BST20160078. PMID 27528751. S2CID 206156045.

NUDT21 information

and 7 Related for: NUDT21 information

NUDT21

Cleavage factor

Cleavage and polyadenylation specificity factor

Chromosome 12 open reading frame 71

TMEM267

Hyaluronan synthase

CPSF7