Simplified illustration of extracellular purinergic signalling
Concepts
Purinergic signalling
Receptors
Pannexins
Ectonucleotidases
Metabolism
Membrane transporters
Nucleoside transporters
Concentrative
Equilibrative
v
t
e
Pannexin
Identifiers
Symbol
Pannexin
InterPro
IPR039099
TCDB
1.A.25
pannexin 1
Identifiers
Symbol
PANX1
NCBI gene
24145
HGNC
8599
OMIM
608420
RefSeq
NM_015368
UniProt
Q96RD7
Other data
Locus
Chr. 11 q14-q21
Search for
Structures
Swiss-model
Domains
InterPro
pannexin 2
Identifiers
Symbol
PANX2
NCBI gene
56666
HGNC
8600
OMIM
608421
RefSeq
NM_052839
UniProt
Q96RD6
Other data
Locus
Chr. 22 q13
Search for
Structures
Swiss-model
Domains
InterPro
pannexin 3
Identifiers
Symbol
PANX3
NCBI gene
116337
HGNC
20573
OMIM
608422
RefSeq
NM_052959
UniProt
Q96QZ0
Other data
Locus
Chr. 11 q24.2
Search for
Structures
Swiss-model
Domains
InterPro
Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate innexins.[1] While innexins are responsible for forming gap junctions in invertebrates, the pannexins have been shown to predominantly exist as large transmembrane channels connecting the intracellular and extracellular space, allowing the passage of ions and small molecules between these compartments (such as ATP and sulforhodamine B).
Three pannexins have been described in Chordates: Panx1, Panx2 and Panx3.[2]
^Panchin Y, Kelmanson I, Matz M, Lukyanov K, Usman N, Lukyanov S (June 2000). "A ubiquitous family of putative gap junction molecules". Current Biology. 10 (13): R473-4. Bibcode:2000CBio...10.R473P. doi:10.1016/S0960-9822(00)00576-5. PMID 10898987. S2CID 20001454.
^Litvin O, Tiunova A, Connell-Alberts Y, Panchin Y, Baranova A (2006). "What is hidden in the pannexin treasure trove: the sneak peek and the guesswork". Journal of Cellular and Molecular Medicine. 10 (3): 613–34. doi:10.1111/j.1582-4934.2006.tb00424.x. PMC 3933146. PMID 16989724.
Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate...
reducing its deposition in various tissues. Probenecid also inhibits pannexin 1. Pannexin 1 is involved in the activation of inflammasomes and subsequent release...
Pannexin 1 is a protein in humans that is encoded by the PANX1 gene. The protein encoded by this gene belongs to the innexin family. Innexin family members...
Furthermore, pannexins appear to do this to such an extent they may rarely if ever participate in direct cell to cell coupling. As indicated on the pannexin/innexin/connexin...
"Cell-to-cell communication in intact taste buds through ATP signalling from pannexin 1 gap junction hemichannels". The Journal of Physiology. 587 (Pt 24): 5899–906...
in vivo in the same way connexins do. The more recently characterized pannexin family, which was originally thought to form intercellular channels (with...
one-half of a gap junction channel. Hemichannels consist of connexins. Pannexins are involved in the process of purinergic signalling. They release adenosine...
by MITF. Activation of the P2X7 receptor by ATP leads to recruitment of pannexin pores which allow small molecules such as ATP to leak out of cells. This...
IP3 and cause release of ATP through channels in the membrane made of pannexins. The net effect is a calcium wave that propagates from cell to cell. Extracellular...
beaded apoptopodia (the latter having a beads-on-a-string appearance). Pannexin 1 is an important component of membrane channels involved in the formation...
odontoblast-neuron signal communication via Piezo1/TRPA1 channels and pannexin-1 in odontoblasts and P2X3 receptors in A-delta neuron is involved in the...
case, the final product of the hydrolysis cascade is the nucleoside. The Pannexin-1 channel (PANX1) is an integral component of the P2X/P2Y purinergic signaling...
gap junctions. Instead, the channels formed by these proteins (called pannexins) act as very large transmembrane pores that connect the intra- and extracellular...
matrix Role of cell adhesions in neural development Cell adhesion molecules Pannexin, vertebrate proteins used to form conduits between the intracellular and...
slow with a time constant of about 200 ms and depends on ATP release via Pannexin 1 channels located on horizontal cell dendrites invaginating the cone synaptic...
regulator (CFTR), and a final conduit that transport ATP to vascular lumen (pannexin 1 or voltage-dependent anion channel (VDAC)). The released ATP acts on...
signaling. Spironolactone has been found to act as a potent inhibitor of the pannexin 1 channel, and this action appears to be involved in its antihypertensive...
called "pannexins" (from the Greek pan - all, throughout, and Latin nexus - connection, bond). However, increasing evidence suggests that pannexins do not...
Kim, M. J; Huh, T. L; Ryoo, Z. Y; Kim, U. K; Bok, J; Lee, K. Y (2015). "Pannexin 3 is required for normal progression of skeletal development in vertebrates"...
a wider family of proteins that are innexin homologues referred to as pannexins. So far Vinnexins have only been found in Adenovirus and the way they...
Liu YP, Zhao HB (January 2009). "Identification and characterization of pannexin expression in the mammalian cochlea". J. Comp. Neurol. 512 (3): 336–46...
Fátima; Silva-Ramos, Miguel; Correia-de-Sá, Paulo (2014). "ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6...
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