Not to be confused with Interstitial nucleus of Cajal and Horizontal cells of Cajal.
For the cell in the midbrain, see Rostral interstitial nucleus of medial longitudinal fasciculus.
Interstitial cell of Cajal
Details
Identifiers
Latin
cellulae interstitiales stimulantes[1]
MeSH
D056885
FMA
86573
Anatomical terminology
[edit on Wikidata]
Interstitial cells of Cajal (ICC) are interstitial cells found in the gastrointestinal tract. There are different types of ICC with different functions. ICC and another type of interstitial cell, known as platelet-derived growth factor receptor alpha (PDGFRα) cells, are electrically coupled to smooth muscle cells via gap junctions, that work together as an SIP functional syncytium.[2] Myenteric interstitial cells of Cajal (ICC-MY) serve as pacemaker cells that generate the bioelectrical events known as slow waves.[3] Slow waves conduct to smooth muscle cells and cause phasic contractions.[4][5]
An isolated Interstitial cell of Cajal from the myenteric plexus of the mouse small intestine grown in a primary cell culture.
The picture to the right shows an isolated Interstitial cell of Cajal from the Myenteric plexus of the mouse small intestine grown in a primary cell culture. This cell type can be characterized morphologically as having a small cell body often triangular or stellate-shaped with several long processes branching out into secondary and tertiary extensions - these processes often contact smooth muscle cells. They have contractile behaviour in both the cell body and the extended processes.
^"Duodenum Dr.Jastrows EM-Atlas".
^Song, NN; Xu, WX (25 October 2016). "[Physiological and pathophysiological meanings of gastrointestinal smooth muscle motor unit SIP syncytium]". Sheng li xue bao: [Acta Physiologica Sinica]. 68 (5): 621–627. PMID 27778026.
^Thomsen, L.; Robinson, T. L.; Lee, J. C.; Farraway, L. A.; Hughes, M. J.; Andrews, D. W.; Huizinga, J. D. (1 July 1998). "Interstitial cells of Cajal generate a rhythmic pacemaker current". Nature Medicine. 4 (7): 848–851. doi:10.1038/nm0798-848. ISSN 1078-8956. PMID 9662380. S2CID 23987930.
^Hennig GW, Spencer NJ, Jokela-Willis S, Bayguinov PO, Lee HT, Ritchie LA, Ward SM, Smith TK, Sanders KM (May 2010). "ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine". Neurogastroenterol. Motil. 22 (5): e138–51. doi:10.1111/j.1365-2982.2009.01448.x. PMC 2856807. PMID 20059699.
^Sanders K, Koh S, Ward S (2006). "Interstitial cells of cajal as pacemakers in the gastrointestinal tract". Annu Rev Physiol. 68: 307–343. doi:10.1146/annurev.physiol.68.040504.094718. PMID 16460275.
and 24 Related for: Interstitial cell of Cajal information
Interstitialcell refers to any cell that lies in the spaces between the functional cellsof a tissue. Examples include: InterstitialcellofCajal (ICC)...
mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitialcellofCajal, or similar cells. They are defined...
chronic fatigue syndrome (myalgic encephalomyelitis) InterstitialcellofCajal, a type ofinterstitialcell found in the gastrointestinal tract Intraclass...
philanthropist Cajal Institute, a neuroscience research center in Madrid, Spain. CajalcellsCajal–Retzius cellInterstitialcellofCajal (ICC) Cajal bodies...
erythrocytes ("blood"), a layer of white blood cells ("phlegm") and a layer of clear yellow serum ("yellow bile"). Excesses of black bile and yellow bile were...
gastrointestinal tract is activated by a composite of smooth muscle cells (SMCs), interstitialcellsofCajal (ICCs), and platelet-derived growth factor receptor...
depolarization and repolarization of pacemaker cells known as interstitialcellsofCajal (ICCs) in the smooth muscle of the stomach, small intestine, and...
biochemical control of endothelial cells that form the blood–brain barrier, provision of nutrients to the nervous tissue, maintenance of extracellular ion...
type ofinterstitial (stromal) cells with very long (tens to hundreds of micrometres) and very thin prolongations (mostly below the resolving power of light...
equal number of bacterial cells. The exact count has not yet been empirically measured in its entirety and is based on smaller samples of empirical observation...
reflex depends upon an intact network ofinterstitialcellsofCajal in the internal anal sphincter. These cells, which are mediated at least in part by...
Al-Shboul OA (2013). "The importance ofinterstitialcellsofcajal in the gastrointestinal tract". Saudi Journal of Gastroenterology. 19 (1): 3–15. doi:10...
controls peristalsis. Activity is initiated by the pacemaker cells (interstitialcellsofCajal). The gut has intrinsic peristaltic activity (basal electrical...
controls peristalsis. Activity is initiated by the pacemaker cells (interstitialcellsofCajal). The gut has intrinsic peristaltic activity (basal electrical...
muscle, epithelial cells, vomeronasal neurons, olfactory sustentacular cells, and is highly expressed in interstitialcellsofCajal (ICC) throughout the...
dendritic cells, adipocytes, interstitialcellsofCajal and inflammatory cells, such as macrophages and mast cells), serve a variety of structural and immune...
degeneration of glial neurons in the myenteric plexus and the interstitialcellsofCajal lead to slowed intestinal movement and consequently fecal content...
tissue of the gastrointestinal tract and form from the rapid growth ofinterstitialcellsofCajal (ICCs). GISTs are the most common type of tumor found...
Global Information