cysteine-type endopeptidase activity involved in apoptotic process
Pyrin domain binding
cysteine-type endopeptidase activator activity involved in apoptotic process
myosin I binding
tropomyosin binding
protease binding
transmembrane transporter binding
protein dimerization activity
cysteine-type endopeptidase activity
Cellular component
cytoplasm
NLRP3 inflammasome complex
NLRP1 inflammasome complex
AIM2 inflammasome complex
nucleolus
endoplasmic reticulum
mitochondrion
IkappaB kinase complex
nucleus
secretory granule lumen
azurophil granule lumen
extracellular region
cytosol
protein-containing complex
neuronal cell body
Golgi membrane
Golgi apparatus
membrane
Biological process
positive regulation of cysteine-type endopeptidase activity
regulation of apoptotic process
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of adaptive immune response
defense response to Gram-negative bacterium
immune system process
cellular response to tumor necrosis factor
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of DNA-binding transcription factor activity
tumor necrosis factor-mediated signaling pathway
positive regulation of JNK cascade
negative regulation of interferon-beta production
negative regulation of I-kappaB kinase/NF-kappaB signaling
myeloid dendritic cell activation
positive regulation of T cell activation
defense response to virus
cellular response to interleukin-1
positive regulation of apoptotic process
positive regulation of tumor necrosis factor production
positive regulation of release of cytochrome c from mitochondria
negative regulation of protein serine/threonine kinase activity
positive regulation of extrinsic apoptotic signaling pathway
inflammatory response
cellular response to lipopolysaccharide
negative regulation of NF-kappaB transcription factor activity
signal transduction
apoptotic process
innate immune response
neutrophil degranulation
positive regulation of NF-kappaB transcription factor activity
activation of innate immune response
myeloid dendritic cell activation involved in immune response
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of actin filament polymerization
regulation of protein stability
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
positive regulation of activated T cell proliferation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
macropinocytosis
positive regulation of phagocytosis
positive regulation of ERK1 and ERK2 cascade
positive regulation of T cell migration
positive regulation of defense response to virus by host
intrinsic apoptotic signaling pathway in response to DNA damage
response to bacterium
regulation of autophagy
interleukin-1 beta production
regulation of GTPase activity
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of inflammatory response
protein homooligomerization
activation of cysteine-type endopeptidase activity
negative regulation of cytokine production involved in inflammatory response
proteolysis
positive regulation of interleukin-1 beta production
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
29108
66824
Ensembl
ENSG00000103490
ENSMUSG00000030793
UniProt
Q9ULZ3
Q9EPB4
RefSeq (mRNA)
NM_145183 NM_013258 NM_145182
NM_023258
RefSeq (protein)
NP_037390 NP_660183
NP_075747
Location (UCSC)
Chr 16: 31.2 – 31.2 Mb
Chr 7: 127.59 – 127.59 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene.[5] It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, perinuclear space, endoplasmic reticulum and mitochondria and it is a key adaptor protein in activation of the inflammasome.[6]
NMR structure of full-length ASC: PDB ID 2KN6 [1][7]
^ abcGRCh38: Ensembl release 89: ENSG00000103490 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030793 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: PYCARD PYD and CARD domain containing". Retrieved 18 September 2010.
^Dunn JH, Fujita M (2015). "PYCARD (PYD and CARD domain containing)". Atlas of Genetics and Cytogenetics in Oncology and Haematology (4). doi:10.4267/2042/56440 (inactive 2024-04-12). hdl:2042/56440. ISSN 1768-3262.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
^Alba Ed (2009-11-20). "Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)". Journal of Biological Chemistry. 284 (47): 32932–32941. doi:10.1074/jbc.M109.024273. ISSN 0021-9258. PMC 2781708. PMID 19759015.
PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene...
Pycard, also spelt Picard and Picart (late 14th century – early 15th century) was an English or French Medieval and Renaissance transitional composer....
musicians may also have been known in England. It has been suggested that Pycard, composer of the canon No. 75, was actually French; but this is unlikely...
Purcell (1659–1695) Kevin Puts (born 1972) Veli-Matti Puumala (born 1965) Pycard (Picart) (fl. c. 1410) Qu Xiaosong (born 1952) Qu Xixian (1919–2008) Johannes...
(NLR) subfamily of PRRs and NLRP3 together with the adaptor ASC protein PYCARD forms a caspase-1 activating complex known as the NLRP3 inflammasome. NLRP3...
Apoptosis-associated speck-like protein containing a CARD, a protein encoded by the PYCARD gene Application Session Controller, an element of a telecommunications...
apoptosis-associated speck like protein containing a CARD (also known as ASC or Pycard), which then recruits pro-caspase-1 via its CARD domain to activate inflammatory...
as Jovannes de Florentia, Giovanni degli Organi and Giovanni di Niccol Pycard fl. c. 1390-after c. 1410 English Has works preserved in the first layer...
(14th century; died 1373?) Aleyn (fl. c. 1400) Byttering (fl. c. 1410–1420) Pycard (fl. c. 1410) Roy Henry (fl. c. 1410) Leonel Power (c. 1370/1385–1445) John...
cause cytosolic NLRP3 (i.e., NLR family pyrin domain containing 3) to bind PYCARD (i.e., apoptosis-associated speck-like protein containing a CARD) which...
(subscription or UK public library membership required) Bent, Margaret (2001). "(1) Pycard [Picart]". Grove Music Online. Oxford: Oxford University Press. doi:10...
Ciconia and Guillaume Du Fay. A 15th-century mass by a composer known only as Pycard found in the Old Hall manuscript (named for the English town in which it...
activity of two proteins associated with the inflammasome; caspase-1 and PYCARD. ENSG00000281166, ENSG00000182261 GRCh38: Ensembl release 89: ENSG00000276780...
1281 when he brought a lawsuit at Westminster against Joanna Pycard, widow of William Pycard, for possession of the Manor of Goldington, Bedfordshire. The...
Resurexit victor mortis. He is probably not related to the English composer Pycard, but may be the same as Arnold Pickar, a cleric and cantor for Frederick...
Drakelowe, occurs 1405 and 1413 Elizabeth Chiltern, resigned 1470 Margaret Pycard, elected 1470 Helen Crabbe, died 1501 Eleanor Pygot, elected 1501, died...
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