NLRP10 information

NLRP10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M5V
Identifiers
Aliases	NLRP10, CLR11.1, NALP10, NOD8, PAN5, PYNOD, NLR family, pyrin domain containing 10, NLR family pyrin domain containing 10
External IDs	OMIM: 609662; MGI: 2444084; HomoloGene: 18468; GeneCards: NLRP10; OMA:NLRP10 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	7,965,447 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	108,529,385 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; testicle; ; skin of abdomen; ; stromal cell of endometrium; ; placenta; ; Achilles tendon; ; appendix; ; gastrocnemius muscle; ; lactiferous gland; ; smooth muscle tissue;
	Top expressed in
	interventricular septum; ; esophagus; ; lip; ; skin of external ear; ; myocardium of ventricle; ; skin of back; ; belly cord; ; atrioventricular valve; ; skin of abdomen; ; atrium;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATP binding; GTPase activity; ATPase activity;
Cellular component	plasma membrane; extrinsic component of plasma membrane; membrane; cytoplasm;
Biological process	innate immune response; adaptive immune response; defense response to Gram-negative bacterium; immune system process; positive regulation of T-helper 17 type immune response; defense response to fungus; positive regulation of T-helper 1 type immune response; positive regulation of inflammatory response; positive regulation of defense response to bacterium; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	338322
	244202
	ENSG00000276780; ENSG00000281166; ENSG00000182261
	ENSMUSG00000049709
	Q86W26
	Q8CCN1
	NM_176821; NM_001391958
	NM_175532
	NP_789791
	NP_780741
	Wikidata
View/Edit Human	View/Edit Mouse

NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response. NLRP10 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.^[5]^[6]

^ ^a ^b ^c ENSG00000281166, ENSG00000182261 GRCh38: Ensembl release 89: ENSG00000276780, ENSG00000281166, ENSG00000182261 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049709 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Y, Hasegawa M, Imamura R, et al. (June 2004). "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1". Int. Immunol. 16 (6): 777–86. doi:10.1093/intimm/dxh081. hdl:2297/15871. PMID 15096476.
^ Imamura R, Wang Y, Kinoshita T, et al. (May 2010). "Anti-inflammatory activity of PYNOD and its mechanism in humans and mice". J. Immunol. 184 (10): 5874–84. doi:10.4049/jimmunol.0900779. PMID 20393137.

[refGRCh38Ensembl-1] ENSG00000281166, ENSG00000182261 GRCh38: Ensembl release 89: ENSG00000276780, ENSG00000281166, ENSG00000182261 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049709 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15096476-5] Wang Y, Hasegawa M, Imamura R, et al. (June 2004). "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1". Int. Immunol. 16 (6): 777–86. doi:10.1093/intimm/dxh081. hdl:2297/15871. PMID 15096476.

[pmid20393137-6] Imamura R, Wang Y, Kinoshita T, et al. (May 2010). "Anti-inflammatory activity of PYNOD and its mechanism in humans and mice". J. Immunol. 184 (10): 5874–84. doi:10.4049/jimmunol.0900779. PMID 20393137.

NLRP10 information

and 6 Related for: NLRP10 information

NLRP10

NLRP

Inflammasome

NACHT domain

Pyrin domain

Outline of immunology