PUM2 information

PUM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3Q0Q, 3Q0R, 3Q0S
Identifiers
Aliases	PUM2, PUMH2, PUML2, pumilio RNA binding family member 2
External IDs	OMIM: 607205; MGI: 1931751; HomoloGene: 69183; GeneCards: PUM2; OMA:PUM2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	20,352,234 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	8,802,581 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; middle temporal gyrus; ; ventricular zone; ; tibia; ; Achilles tendon; ; skin of thigh; ; cerebellar vermis; ; epithelium of nasopharynx; ; ganglionic eminence; ; bronchial epithelial cell;
	Top expressed in
	medial ganglionic eminence; ; Region I of hippocampus proper; ; human fetus; ; foot; ; cingulate gyrus; ; ciliary body; ; mesenteric lymph nodes; ; ventricular zone; ; entorhinal cortex; ; tail of embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; mRNA 3'-UTR binding; miRNA binding;
Cellular component	perinuclear region of cytoplasm; cytoplasmic stress granule; nuclear membrane; cytoplasm; cytosol;
Biological process	regulation of chromosome segregation; regulation of gene silencing by miRNA; positive regulation of RIG-I signaling pathway; regulation of translation; regulation of mRNA stability; positive regulation of gene silencing by miRNA; stress granule assembly; posttranscriptional regulation of gene expression; production of miRNAs involved in gene silencing by miRNA;
	Sources:Amigo / QuickGO
Orthologs
	23369
	80913
	ENSG00000055917
	ENSMUSG00000020594
	Q8TB72
	Q80U58
NM_001282752; NM_001282790; NM_001282791; NM_015317; NM_001352917;
	NM_001352918; NM_001352919; NM_001352920; NM_001352923; NM_001352925; NM_001352926; NM_001352927; NM_001352928; NM_001352929; NM_001352930
NM_001160219; NM_001160220; NM_001160221; NM_001160222; NM_030723;
	NM_001310519
NP_001269681; NP_001269719; NP_001269720; NP_056132; NP_001339846;
	NP_001339847; NP_001339848; NP_001339849; NP_001339852; NP_001339854; NP_001339855; NP_001339856; NP_001339857; NP_001339858; NP_001339859
NP_001153691; NP_001153692; NP_001153693; NP_001153694; NP_001297448;
	NP_109648
	Wikidata
View/Edit Human	View/Edit Mouse

Pumilio homolog 2 is an RNA-binding protein that in humans is encoded by the PUM2 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000055917 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020594 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
^ Spassov DS, Jurecic R (Dec 2002). "Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins". Gene. 299 (1–2): 195–204. doi:10.1016/S0378-1119(02)01060-0. PMID 12459267.
^ Moore FL, Jaruzelska J, Fox MS, Urano J, Firpo MT, Turek PJ, Dorfman DM, Pera RA (Jan 2003). "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-Like proteins". Proc Natl Acad Sci U S A. 100 (2): 538–43. Bibcode:2003PNAS..100..538M. doi:10.1073/pnas.0234478100. PMC 141031. PMID 12511597.
^ "Entrez Gene: PUM2 pumilio homolog 2 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000055917 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020594 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9039502-5] Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.

[pmid12459267-6] Spassov DS, Jurecic R (Dec 2002). "Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins". Gene. 299 (1–2): 195–204. doi:10.1016/S0378-1119(02)01060-0. PMID 12459267.

[pmid12511597-7] Moore FL, Jaruzelska J, Fox MS, Urano J, Firpo MT, Turek PJ, Dorfman DM, Pera RA (Jan 2003). "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-Like proteins". Proc Natl Acad Sci U S A. 100 (2): 538–43. Bibcode:2003PNAS..100..538M. doi:10.1073/pnas.0234478100. PMC 141031. PMID 12511597.

[entrez-8] "Entrez Gene: PUM2 pumilio homolog 2 (Drosophila)".

PUM2 information

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