The DAZ (Deleted in AZoospermia) protein family is a group of three highly conserved RNA-binding proteins that are important in gametogenesis and meiosis. Therefore, mutations in the genes that encode for the DAZ proteins can have detrimental consequences for fertility.[1]
The three members of the DAZ protein family include BOULE (BOLL), DAZL (DAZLA) and DAZ (DAZ1, DAZ2, DAZ3 and DAZ4). DAZ1 is located on the Y chromosome in higher primates and is important for spermatogenesis. BOULE and DAZL are important for both oogenesis and spermatogenesis. BOULE and DAZL are both located on autosomes as single copies. However DAZ is located with multiple copies in the Y chromosome only. BOULE is present from invertebrates, DAZL is from vertebrates and DAZ is present from primates.[2]
^Fu XF, Cheng SF, Wang LQ, Yin S, De Felici M, Shen W (2015). "DAZ Family Proteins, Key Players for Germ Cell Development". International Journal of Biological Sciences. 11 (10): 1226–35. doi:10.7150/ijbs.11536. PMC 4551758. PMID 26327816.
^Reynolds N, Cooke HJ (January 2005). "Role of the DAZ genes in male fertility". Reproductive Biomedicine Online. 10 (1): 72–80. doi:10.1016/s1472-6483(10)60806-1. PMID 15705297.
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