Type I neuroblast gives rise to a GMC and an identical neuroblast, as opposed to type II whose daughter cells are known as intermediate neural progenitors (INPs). The GMC then differentiates into two neurons.[1]
Ganglion mother cells (GMCs) are cells involved in neurogenesis, in non-mammals, that divide only once to give rise to two neurons, or one neuron and one glial cell or two glial cells,[2] and are present only in the central nervous system. They are also responsible for transcription factor expression. While each ganglion mother cell necessarily gives rise to two neurons, a neuroblast can asymmetrically divide multiple times.[3] GMCs are the progeny of type I neuroblasts. Neuroblasts asymmetrically divide during embryogenesis to create GMCs.[4] GMCs are only present in certain species and only during the embryonic and larval stages of life. Recent research has shown that there is an intermediate stage between a GMC and two neurons. The GMC forms two ganglion cells which then develop into neurons or glial cells.[5] Embryonic neurogenesis has been extensively studied in Drosophila melanogaster embryos and larvae.
the signal protein Notch is exposed to both daughter cells of a neuroblast (another neuroblast and a GMC). Because Numb (represented by the blue line) is a Notch suppressor and only present in the GMC, the GMC will behave differently from the other daughter cell, the neuroblast.
^Bayraktar, Boone, Drummond, Doe (2010). Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex. Neural Development, 5:26.
^Cite error: The named reference Karcavich was invoked but never defined (see the help page).
^Doe, C. Q. et al (2008). Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells. PMC 2804867.
^Doe, C. Q. (1992). Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system. Development, 116(4), 855-863.
^Colonques, Jordi, Ceron, Julian, Reichert, Heinrich, & Tejedor, Francisco J. (2011). A transient expression of Prospero promotes cell cycle exit of Drosophila postembryonic neurons through the regulation of Dacapo. PLoS ONE, 6(4), e19342-e19342.
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Ganglionmothercells (GMCs) are cells involved in neurogenesis, in non-mammals, that divide only once to give rise to two neurons, or one neuron and one...
neurophysiology, a ganglioncell is a cell found in a ganglion (a cluster of neurons in the peripheral nervous system). Examples of ganglioncells include: Retinal...
is a neural progenitor cell which divides asymmetrically to produce a neuroblast and either a neuron, a ganglionmothercell (GMC), or an intermediate...
neural precursor cells, called neuroblasts. In drosophila, neuroblasts divide asymmetrically, so that one product is a "ganglionmothercell" (GMC), and the...
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axons continue away from the CNS to synapse at an autonomic ganglion. The parasympathetic ganglion where these preganglionic neurons synapse will be close...
cells are irreversibly determined by approximately the mid-tailbud stage (21 hrs). Equivalence groups have also been described in the ganglionmother...
a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the...
Carl Weigert, she conducted research that led to the discovery of the ganglioncell of the ovary, and published a major paper on the subject in 1896. In...
studies of cultured cells. He contributed to the study of the nervous system, especially on the plasticity of sensory ganglioncells. While in Turin, he...
in neuronal cell bodies, and virions are shed from the cells and carried down the axons to the area of skin innervated by that ganglion. In the skin...
midline of the developing spinal cord. Specifically, SHH attracts retinal ganglioncell (RGC) axons at low concentrations and repels them at higher concentrations...
fractal sets to the analysis of neuritic patterns of cultured cat retinal ganglioncells (1988) Doctoral advisor Michael Friedlander Other academic advisors...
neuroendocrine system is typical of insects. There is a brain, a subesophageal ganglion, three thoracic ganglia, and six abdominal ganglia. Strong neuron connections...
developed methods for the purification and culturing of retinal ganglioncells and the glial cells with which they interact, including the oligodendrocytes and...
respiratory distress type 1 Atypical motor neuron diseases Dorsal root ganglion disorders A neuropathy affects the peripheral nerves. Guillain–Barré syndrome...
such as achalasia or Chagas disease. Achalasia is caused by a loss of ganglioncells in the myenteric plexus. There is a marked lack of contraction within...
The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature...
cell (NF-B) pathways, while promoting expression of key tumor-suppressive molecules including phosphatase and tensin homolog, E-cadherin, and mothers...
segment. The ventral nerve cord has a swelling, or ganglion, in each segment, i.e. a segmental ganglion, which occurs from the fifth to the last segment...
Martin/Georgie is in a cell: No puppet master pulls the strings on high Proportioning our parts, the tinsel and the paint A twisted nerve, a ganglion gone awry, Predestinates...
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