SMG1 information

SMG1
Identifiers
Aliases	SMG1, 61E3.4, ATX, LIP, nonsense mediated mRNA decay associated PI3K related kinase, SMG1 nonsense mediated mRNA decay associated PI3K related kinase
External IDs	OMIM: 607032; MGI: 1919742; HomoloGene: 56697; GeneCards: SMG1; OMA:SMG1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	18,926,408 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	117,842,893 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; sural nerve; ; epithelium of colon; ; skin of hip; ; Achilles tendon; ; epithelium of nasopharynx; ; parietal pleura; ; mucosa of sigmoid colon; ; visceral pleura; ; jejunal mucosa;
	Top expressed in
	tail of embryo; ; genital tubercle; ; lobe of cerebellum; ; cerebellar vermis; ; mesenteric lymph nodes; ; medullary collecting duct; ; Rostral migratory stream; ; renal corpuscle; ; neural layer of retina; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	telomeric DNA binding; ATP binding; protein kinase activity; protein binding; kinase activity; metal ion binding; nucleotide binding; transferase activity; protein serine/threonine kinase activity; RNA binding;
Cellular component	nucleus; cytosol; cytoplasm; nucleoplasm;
Biological process	response to stress; mRNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; peptidyl-serine phosphorylation; phosphatidylinositol phosphate biosynthetic process; cellular response to DNA damage stimulus; protein autophosphorylation; phosphorylation; regulation of telomere maintenance; DNA repair; regulation of response to DNA damage stimulus; protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23049
	233789
	ENSG00000157106
	ENSMUSG00000030655
	Q96Q15
	Q8BKX6
	NM_015092
	NM_001031814; NM_177180
	NP_055907
	NP_001026984
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene.^[5]^[6]^[7]^[8] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157106 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030655 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
^ Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (June 2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. 276 (25): 22709–14. doi:10.1074/jbc.C100144200. PMID 11331269.
^ Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S (March 2007). "Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay". J. Biol. Chem. 282 (11): 7799–808. doi:10.1074/jbc.M610159200. PMID 17229728.
^ "Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157106 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030655 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9455477-5] Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.

[pmid11331269-6] Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (June 2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. 276 (25): 22709–14. doi:10.1074/jbc.C100144200. PMID 11331269.

[pmid17229728-7] Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S (March 2007). "Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay". J. Biol. Chem. 282 (11): 7799–808. doi:10.1074/jbc.M610159200. PMID 17229728.

[entrez-8] "Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1".

SMG1 information

and 7 Related for: SMG1 information

SMG1

Exon junction complex

Stress granule

MRNA surveillance

SMG6

UPF1

PRKCI