PPP2R1A information

PPP2R1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B3U, 2IE3, 2IE4, 2NPP, 2NYL, 2NYM, 2PKG, 3C5W, 3DW8, 3K7V, 3K7W, 4I5L, 4I5N, 4LAC,%%s2IE4, 2NPP, 2IE3, 3K7V, 3K7W
Identifiers
Aliases	PPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA
External IDs	OMIM: 605983; MGI: 1926334; HomoloGene: 68559; GeneCards: PPP2R1A; OMA:PPP2R1A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	52,229,518 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	21,186,178 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; ganglionic eminence; ; right frontal lobe; ; right hemisphere of cerebellum; ; ventricular zone; ; right adrenal cortex; ; prefrontal cortex; ; cingulate gyrus; ; right auricle; ; left adrenal cortex;
	Top expressed in
	vestibular membrane of cochlear duct; ; motor neuron; ; facial motor nucleus; ; primitive streak; ; endothelial cell of lymphatic vessel; ; anterior horn of spinal cord; ; vas deferens; ; ciliary body; ; medial ganglionic eminence; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine phosphatase activity; protein binding; protein heterodimerization activity; protein phosphatase regulator activity; protein antigen binding;
Cellular component	cytoplasm; cytosol; microtubule cytoskeleton; protein phosphatase type 2A complex; chromosome; mitochondrion; chromosome, centromeric region; extracellular exosome; nucleus; plasma membrane; membrane; lateral plasma membrane; dendrite; cell projection; synapse; glutamatergic synapse;
Biological process	apoptotic process; regulation of meiotic cell cycle process involved in oocyte maturation; meiotic sister chromatid cohesion, centromeric; regulation of transcription, DNA-templated; ceramide metabolic process; regulation of DNA replication; chromosome segregation; protein dephosphorylation; meiotic spindle elongation; female meiotic nuclear division; response to organic substance; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; peptidyl-serine dephosphorylation; regulation of Wnt signaling pathway; regulation of cell adhesion; G2/M transition of mitotic cell cycle; negative regulation of cell growth; RNA splicing; regulation of cell differentiation; regulation of growth; mitotic nuclear membrane reassembly; mitotic sister chromatid separation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; second-messenger-mediated signaling; ciliary basal body-plasma membrane docking; negative regulation of tyrosine phosphorylation of STAT protein; regulation of G2/M transition of mitotic cell cycle; regulation of phosphoprotein phosphatase activity; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	5518
	51792
	ENSG00000105568
	ENSMUSG00000007564
	P30153
	Q76MZ3
	NM_014225; NM_001363656
	NM_016891
	NP_055040; NP_001350585; NP_055040.2
	NP_058587
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene.^[5] In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105568 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007564 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Everett AD, Xue C, Stoops T (August 1999). "Developmental expression of protein phosphatase 2A in the kidney". J. Am. Soc. Nephrol. 10 (8): 1737–45. doi:10.1681/ASN.V1081737. PMID 10446941.
^ Haynes JG, Hartung AJ, Hendershot JD, Passingham RS, Rundle SJ (February 1999). "Molecular characterization of the B' regulatory subunit gene family of Arabidopsis protein phosphatase 2A". Eur. J. Biochem. 260 (1): 127–136. doi:10.1046/j.1432-1327.1999.00154.x. PMID 10091592.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105568 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007564 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10446941-5] Everett AD, Xue C, Stoops T (August 1999). "Developmental expression of protein phosphatase 2A in the kidney". J. Am. Soc. Nephrol. 10 (8): 1737–45. doi:10.1681/ASN.V1081737. PMID 10446941.

[pmid10091592-6] Haynes JG, Hartung AJ, Hendershot JD, Passingham RS, Rundle SJ (February 1999). "Molecular characterization of the B' regulatory subunit gene family of Arabidopsis protein phosphatase 2A". Eur. J. Biochem. 260 (1): 127–136. doi:10.1046/j.1432-1327.1999.00154.x. PMID 10091592.

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