endoplasmic reticulum-endosome membrane contact site
Biological process
steroid metabolic process
progesterone biosynthetic process
lipid transport
cholesterol metabolic process
mitochondrial transport
lipid metabolism
C21-steroid hormone biosynthetic process
cholesterol transport
vesicle tethering to endoplasmic reticulum
transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10948
59045
Ensembl
ENSG00000131748
ENSMUSG00000018167
UniProt
Q14849
Q61542
RefSeq (mRNA)
NM_001165937 NM_001165938 NM_006804
NM_021547
RefSeq (protein)
NP_001159409 NP_001159410 NP_006795
NP_067522
Location (UCSC)
Chr 17: 39.64 – 39.66 Mb
Chr 11: 98.25 – 98.27 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
StAR related lipid transfer domain containing 3(STARD3) is a protein that in humans is encoded by the STARD3 gene.[5]STARD3 also known as metastatic lymph node 64 protein (MLN64) is a late endosomal integral membrane protein involved in cholesterol transport.[6] STARD3 creates membrane contact sites between the endoplasmic reticulum (ER) and late endosomes where it moves cholesterol.[7][8]
^ abcGRCh38: Ensembl release 89: ENSG00000131748 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000018167 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: StAR related lipid transfer domain containing 3". Retrieved 2018-08-07.
^Alpy F, Tomasetto C (June 2006). "MLN64 and MENTHO, two mediators of endosomal cholesterol transport". Biochemical Society Transactions. 34 (Pt 3): 343–5. doi:10.1042/BST0340343. PMID 16709157.
^Wilhelm LP, Wendling C, Védie B, Kobayashi T, Chenard MP, Tomasetto C, Drin G, Alpy F (May 2017). "STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites". The EMBO Journal. 36 (10): 1412–1433. doi:10.15252/embj.201695917. PMC 5430228. PMID 28377464.
^Alpy F, Rousseau A, Schwab Y, Legueux F, Stoll I, Wendling C, Spiegelhalter C, Kessler P, Mathelin C, Rio MC, Levine TP, Tomasetto C (December 2013). "STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER". Journal of Cell Science. 126 (Pt 23): 5500–12. doi:10.1242/jcs.139295. PMID 24105263.
and 28 Related for: Star related lipid transfer domain containing 3 information
lipid substrate(s). Membrane binding may also promote rearrangement, dissociation, or conformational changes within many protein structural domains,...
regulatory protein (STAR). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-relatedlipidtransfer (START) domain, including...
its activity. The domain of StAR important for promoting cholesterol transfer is the StAR-relatedtransferdomain (START domain). StAR is the prototypic...
StAR-relatedlipidtransfer protein 10 (STARD10) or PCTP-like protein is a lipidtransfer protein that in humans is encoded by the STARD10 gene. The protein...
also contains the VASt (VAD1 Analog of StAR-relatedlipidtransfer) domain. The VASt domain is predominantly associated with lipid binding domains, such...
StAR-relatedlipidtransferdomain protein 8 (STARD8) also known as deleted in liver cancer 3 protein (DLC-3) is a protein that in humans is encoded by...
"Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2". The Journal of Biological Chemistry. 282 (42):...
Collagen type IV alpha-3-binding protein, also known as ceramide transfer protein (CERT) or StAR-relatedlipidtransfer protein 11 (STARD11) is a protein...
consisting of a few layers of peptidoglycan surrounded by a second lipid membrane containing lipopolysaccharides and lipoproteins. Most bacteria have the Gram-negative...
Stacewicz-Sapuntzakis M, et al. (January 2003). "Serum concentrations of lipids, vitamin d metabolites, retinol, retinyl esters, tocopherols and selected...
Plastoglobuli contain both structural proteins and enzymes involved in lipid synthesis and metabolism. They contain many types of lipids including plastoquinone...
carbon and water, and builds largely upon four key families of chemicals: lipids for cell membranes, carbohydrates such as sugars, amino acids for protein...
Iron-containing proteins participate in transport, storage and use of oxygen. Iron proteins are involved in electron transfer. Examples of iron-containing...
Changes in cellular lipid and effects of respiratory inhibitors and ion-transport modifiers1". Limnology and Oceanography. 22 (3): 539–552. Bibcode:1977LimOc...
Starfish produce a large number of secondary metabolites in the form of lipids, including steroidal derivatives of cholesterol, and fatty acid amides of...
"CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?". Prostaglandins & Other Lipid Mediators. 96 (1–4): 99–108. doi:10.1016/j...
copolymers are sometimes used as a replacement for phospholipids in model lipid bilayers and liposomes for their superior stability and tunability. Polymer...
biosynthesis and S-adenosylmethionine radical enzyme genes, containingdomains involved in electron transfer and catalysis have been detected. Anammox microorganisms...
bluefin tuna (Thunnus maccoyii) is inversely related to the lipid content of tissues". Food Chemistry. 111 (3): 616–621. doi:10.1016/j.foodchem.2008.04.041...
confined in the pores of the metal substrate until the later development of lipid membranes. Another long-standing hypothesis is that the first life was composed...
by a plasma membrane, a bilayer of lipid molecules with many types of protein structures embedded in it. A lipid bilayer is a powerful electrical insulator...
omega-3 polyunsaturated fatty acids is generally associated with the development of chronic diseases and developmental aberrations. Alimentary lipids can...
which could have linked the chemical components into short peptide and lipid chains as well as short RNA-like chains of nucleotides. The RNA world hypothesis...
oxidase and restricting oxygen supply, and carbon monoxide causing brain lipid peroxidation. Carbon monoxide has a higher diffusion coefficient compared...
differences between bacteria, such as cell shape, Gram stain (number of lipid bilayers) or bilayer composition (see Bacterial cellular morphologies, Bacterial...
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