GasderminA is a protein that in humans is encoded by the GSDMA gene. GRCh38: Ensembl release 89: ENSG00000167914 – Ensembl, May 2017 GRCm38: Ensembl release...
Gasdermin D (GSDMD, from combination of gastro and dermato, referencing the locations where its family of proteins were originally found to be primarily...
pro-inflammatory cytokines IL-1β and IL-18, as well as the pore-forming protein gasdermin D. Formation of pores causes cell membrane rupture and release of cytokines...
interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory...
non-infected patients is not uncommon. Gasdermin D (GSDMD) is a protein that in humans is encoded by the GSDMD gene and is a known target of the inflammasome...
substrate for pyroptotic caspases is Gasdermin D (GSDMD) Inflammation is a protective attempt by an organism to restore a homeostatic state, following disruption...
Gasdermin C is a protein that in humans is encoded by the GSDMC gene. GRCm38: Ensembl release 89: ENSMUSG00000056293 – Ensembl, May 2017 "Human PubMed...
Gasdermin B is a protein that in humans is encoded by the GSDMB gene. This gene encodes a member of the gasdermin-domain containing protein family. Other...
formation of the inflammasome which in turn activates Gasdermin D and interleukin 1B. Gasdermin D then forms pores in the membrane and releases the interleukins...
D-aspartate-associated protein 1 (glutamate binding) GSDMC encoding protein Gasdermin C GULOP pseudogene: responsible for human inability to produce Vitamin...
Aglietti, Robin A.; Dueber, Erin C. (April 2017). "Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions"...
as the pore-forming molecule gasdermin D (GSDMD). The N-terminal GSDMD fragment resulting from this cleavage induces a pro-inflammatory form of programmed...
caspase 1 cleaves a) the protein precursors of IL-1β and interleukin 18 into their active pro-inflammatory cytokine forms and b) gasdermin D (also termed...
inflammasome, the pore-forming activity arises from gasdermin D which is cleaved by caspases as a result of the oligomerisation of the NLRs. Plant cells...
caspase-11 in mice, and caspases-1, -4, and -5 in humans, and is executed by gasdermin D. In contrast, necroptosis occurs via RIPK1/3-mediated MLKL activation...
Non-syndromic hearing impairment protein 5 is a protein that in humans is encoded by the DFNA5 gene. Hearing impairment is a heterogeneous condition with over 40...
PMID 16103065. Saeki N, Kim DH, Usui T, et al. (2007). "GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic...
Pejvakin is a protein that in humans is encoded by the PJVK gene. The protein encoded by this gene is a member of the gasdermin family, a family which...
and processes cleavage of pro-IL-1β, pro-IL-18, and gasdermin D. The N-terminal fragment of gasdermin D induces pyroptosis that allows mature cytokines...
marshals ESCRT proteins to repair pores on plasma membrane introduced by gasdermin (GSDMD) during pyroptosis, by MLKL during necroptosis, by Mycobacterium...
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