negative regulation of transcription by RNA polymerase II
transcription by RNA polymerase II
transcription, DNA-templated
nervous system development
multicellular organism development
negative regulation of transcription elongation by RNA polymerase I
central nervous system neuron differentiation
neuron differentiation
positive regulation of apoptotic process
synapse assembly
peripheral nervous system neuron differentiation
mesoderm development
innervation
proprioception involved in equilibrioception
regulation of neurogenesis
sensory system development
suckling behavior
regulation of signal transduction by p53 class mediator
positive regulation of gene expression
neuron projection development
negative regulation of neuron apoptotic process
positive regulation of transcription by RNA polymerase II
negative regulation of programmed cell death
positive regulation of osteoclast differentiation
regulation of DNA-binding transcription factor activity
cellular response to cytokine stimulus
cellular response to estradiol stimulus
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of transcription regulatory region DNA binding
heart development
negative regulation of gene expression
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5457
18996
Ensembl
ENSG00000152192
ENSMUSG00000048349
UniProt
Q01851
P17208
RefSeq (mRNA)
NM_006237
NM_011143
RefSeq (protein)
NP_006228
NP_035273
Location (UCSC)
Chr 13: 78.6 – 78.6 Mb
n/a
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
POU domain, class 4, transcription factor 1 (POU4F1) also known as brain-specific homeobox/POU domain protein 3A (BRN3A), homeobox/POU domain protein RDC-1 or Oct-T1 is a protein that in humans is encoded by the POU4F1 gene.[4][5]
BRN3A (POU4F1) is a class IV POU domain-containing transcription factor highly expressed in the developing peripheral sensory nervous system (dorsal root ganglia, trigeminal ganglion, and hindbrain sensory ganglia), certain regions of the central nervous system, retinal neurons called ganglion cells, and in cells of the B- and T-lymphocytic lineages.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000152192 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Collum RG, Fisher PE, Datta M, Mellis S, Thiele C, Huebner K, Croce CM, Israel MA, Theil T, Moroy T (Sep 1992). "A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system". Nucleic Acids Research. 20 (18): 4919–25. doi:10.1093/nar/20.18.4919. PMC 334251. PMID 1357630.
^ ab"Entrez Gene: POU4F1 POU domain, class 4, transcription factor 1".
^Gerrero MR, McEvilly RJ, Turner E, Lin CR, O'Connell S, Jenne KJ, Hobbs MV, Rosenfeld MG (Nov 1993). "Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs". Proceedings of the National Academy of Sciences of the United States of America. 90 (22): 10841–5. Bibcode:1993PNAS...9010841G. doi:10.1073/pnas.90.22.10841. PMC 47874. PMID 8248179.
POU domain, class 4, transcription factor 1 (POU4F1) also known as brain-specific homeobox/POU domain protein 3A (BRN3A), homeobox/POU domain protein RDC-1...
Homeodomain; POU Known motif – High-throughput in vitro [717] WDAWTTATKCA POU4F1 ENSG00000152192 Homeodomain; POU Known motif – High-throughput in vitro...
(2015). "Red nucleus and rubrospinal tract disorganization in the absence of Pou4f1". Frontiers in Neuroanatomy. 9: 8. doi:10.3389/fnana.2015.00008. ISSN 1662-5129...
interacts with interferon-γ signalling. RIT2 has been shown to interact with POU4F1. GRCh38: Ensembl release 89: ENSG00000152214 – Ensembl, May 2017 GRCm38:...