negative regulation of plasma lipoprotein oxidation
lipid metabolism
carboxylic acid catabolic process
cholesterol metabolic process
positive regulation of binding
response to nutrient levels
response to fluoride
positive regulation of cholesterol efflux
response to external stimulus
organophosphate catabolic process
aromatic compound catabolic process
phosphatidylcholine metabolic process
response to toxic substance
dephosphorylation
lipoxygenase pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5444
18979
Ensembl
ENSG00000005421
ENSMUSG00000002588
UniProt
P27169
P52430
RefSeq (mRNA)
NM_000446
NM_011134
RefSeq (protein)
NP_000437
NP_035264
Location (UCSC)
Chr 7: 95.3 – 95.32 Mb
Chr 6: 5.17 – 5.19 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Paraoxonase 1 (PON1) also known as Serum paraoxonase and arylesterase 1, A esterase, homocysteine thiolactonase or serum aryldialkylphosphatase 1, is an enzyme that in humans is encoded by the PON1 gene.[5] Paraoxonase 1 has esterase and more specifically paraoxonase activity.[6]PON1 is the first discovered member of a multigene family also containing PON2 and PON3, the genes for which are located adjacent to each other on chromosome 7. PON1 on HDL (different from soluble PON1) is responsible for significant atheroprotection rendered by the HDL.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000005421 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002588 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (May 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009.
^van Himbergen TM, van Tits LJ, Roest M, Stalenhoef AF (Feb 2006). "The story of PON1: how an organophosphate-hydrolysing enzyme is becoming a player in cardiovascular medicine". The Netherlands Journal of Medicine. 64 (2): 34–8. PMID 16517986.
^Kumar S, Maniya N, Wang C, Satyajyoti S, Chang HC (Feb 2023). "Quantifying PON1 on HDL with nanoparticle-gated electrokinetic membrane sensor for accurate cardiovascular risk assessment". Nature Communications. 14 (557): 557. Bibcode:2023NatCo..14..557K. doi:10.1038/s41467-023-36258-w. PMC 9895453. PMID 36732521.
Paraoxonase 1 (PON1) also known as Serum paraoxonase and arylesterase 1, A esterase, homocysteine thiolactonase or serum aryldialkylphosphatase 1, is an...
which PON1 can degrade toxic OPs determines the degree of protection that PON1 can provide for organism. The higher the concentration of PON1 the better...
Additional research on the inhibition and selective inhibition, specifically of PON1, has been done to shed some light on the connections between decreases in...
also among veterans with the RR or QR (as opposed to the QQ) forms of the PON1 gene, which produces an enzyme that deactivates organophosphates (including...
sequence of PON1 and its promoter region that may influence the effectiveness of PON1 at detoxifying chlorpyrifos oxon and the amount of PON1 available...
hydrolyzed by the paraoxonase PON3. It was originally thought to be hydrolyzed by PON1, but this was due to contamination with PON3. The majority of spironolactone...
also among veterans with the RR or QR (as opposed to the QQ) forms of the PON1 gene, which produces an enzyme that deactivates organophosphates (including...
Similarly, other research has indicated that people with lower levels of the PON1 gene, which is important for the metabolism of organophosphate pesticides...
detoxified in mammals by an enzyme in the blood and liver called paraoxonase PON1. Willy Lange from Berlin discovered sodium monofluorophosphate in 1929. He...
J, La Du BN (May 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10...
non-pathogenic AAV8 vector to deliver a candidate catalytic bioscavenger, PON1-IF11, to the mouse bloodstream. While 76% of American special operations...
previous models that show the role dietary lead (Pb) and Hg exposures play in PON1 gene inhibition which occurs in both autism and ADHD.Dufault’s updated nutritional...
drank mate tea had a 10% increase in the level of cardioprotective enzyme PON1, a precursor to HDL, compared to others drinking milk or coffee. Dr. De Mejia...
J, La Du BN (Sep 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10...
published models that shows the role dietary lead (Pb) and Hg exposures play in PON1 gene inhibition that occurs in both autism and ADHD.The model was recently...
(February 2010). "Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth". PLOS ONE. 5 (2): e9040. Bibcode:2010PLoSO...5.9040R...
plasticity below). A study of four distinct hydrolases (human serum paraoxonase (PON1), pseudomonad phosphotriesterase (PTE), Protein tyrosine phospatase(PTP)...
Y, Chu X, Wang H, et al. (August 2010). "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene...
Global Information
