Serum paraoxonase/arylesterase 2 is an enzyme that in humans is encoded by the PON2 gene.[5][6][7]
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000105854 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032667 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (Sep 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009.
^Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, Tsui LC, Prochazka M (Aug 1998). "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence". Gene. 213 (1–2): 149–57. doi:10.1016/S0378-1119(98)00193-0. PMID 9714608.
paraoxonase/arylesterase 2 is an enzyme that in humans is encoded by the PON2 gene. This gene encodes a member of the paraoxonase gene family, which includes...
expected to appear only in the GPON space. Passive optical network 10G-PON NG-PON2 "Understand GPON Technology". Cisco. December 6, 2023. Hood, Dave; Trojer...
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There are three known paraoxonases, which are encoded by the genes PON1, PON2 and PON3, located on the long arm of chromosome 7 in humans. The differences...
primary solution for the next-generation passive optical network stage 2 (NG-PON2) by the full service access network (FSAN) in April 2012. TWDM-PON coexists...
systems". ITU. "G.989 : 40-Gigabit-capable passive optical networks (NG-PON2)". ITU. "MoCA 1.1 improves throughput" over coaxial cable to 175 Mbits/s...
the initiative of Calix, Ucom and Calix announced the introduction of NG-PON2 (New Generation Passive Optical Network) technology in Armenia, which would...
A, Osawa Y, Sunahara R, La Du BN (June 2005). "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities"...
PON1 is the first discovered member of a multigene family also containing PON2 and PON3, the genes for which are located adjacent to each other on chromosome...
Draganov DI, Teiber JF, Speelman A, et al. (2005). "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities"...
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