PKD (Polycystic Kidney Disease) domain was first identified in the polycystic kidney disease protein, polycystin-1 (PKD1 gene), and contains an Ig-like fold consisting of a beta-sandwich of seven strands in two sheets with a Greek key topology, although some members have additional strands.[1] Polycystin-1 is a large cell-surface glycoprotein involved in adhesive protein–protein and protein–carbohydrate interactions; however it is not clear if the PKD domain mediates any of these interactions.
PKD domains are also found in other proteins, usually in the extracellular parts of proteins involved in interactions with other proteins. For example, domains with a PKD-type fold are found in archaeal S-layer proteins that protect the cell from extreme environments,[2] and in the human receptor SorCS2.[3]
^Bycroft M, Bateman A, Clarke J, Hamill SJ, Sandford R, Thomas RL, Chothia C (1999). "The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease". EMBO J. 18 (2): 297–305. doi:10.1093/emboj/18.2.297. PMC 1171124. PMID 9889186.
^Joachimiak A, Springer TA, Zhang RG, Wang JH, Liu JH, Jing H, Takagi J, Lindgren S (2002). "Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins". Structure. 10 (10): 1453–1464. doi:10.1016/S0969-2126(02)00840-7. PMID 12377130.
^Hermans-Borgmeyer I, Hampe W, Schaller HC, Rezgaoui M (2001). "The genes for the human VPS10 domain-containing receptors are large and contain many small exons". Hum. Genet. 108 (6): 529–36. doi:10.1007/s004390100504. PMID 11499680. S2CID 23375354.
PKD (Polycystic Kidney Disease) domain was first identified in the polycystic kidney disease protein, polycystin-1 (PKD1 gene), and contains an Ig-like...
transmembrane domains, a large extracellular N-terminal domain, and a short (about 200 amino acid) cytoplasmic C-terminal domain. This intracellular domain contains...
requires PKD kinase activity, while PKD-dependent regulation of TCR signaling to integrins does not appear to require PKD kinase activity. Thus, PKD may play...
exists for a two-hit mechanism (germline and somatic inactivation of two PKD alleles) explaining the focal development of renal and hepatic cysts, haploinsufficiency...
Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)" at ClinicalTrials.gov Clinical trial number NCT03559699 for "A Study Evaluating...
West/The Valentine Press, p.388 ISBN 0-916063-24-0 Levack, Daniel (1981). PKD: A Philip K. Dick Bibliography, Underwood/Miller, p. 131 ISBN 0-934438-33-1...
folded-ear form, as covered in detail below. Polycystic kidney disease (PKD) is prevalent in the Scottish Fold. A study in Japan of cats suspected to...
contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions...
genus Tetracapsuloides. It is the cause of proliferative kidney disease (PKD), one of the most serious parasitic diseases of salmonid populations in Europe...
is associated with these channels. These channels are also referred to as PKD (polycistic kidney disease) ion channels. PKD2-like genes (examples include...
which may mean that Bulero is still trapped in Eldritch's hallucinatory domain, or that Chew-Z is becoming increasingly popular among Terrans and Martian...
The Turning wheel. Pub. 1955-03-14; B00000531302". Levack, Daniel (1981). PKD: A Philip K. Dick Bibliography, Underwood/Miller, p. 129 ISBN 0-934438-33-1...
contiguous with PKD1, the gene involved in one form of polycystic kidney disease (PKD). Gross deletions affecting both genes may account for the 2% of individuals...
pseudosubstrate sequence (PS) domain. PAK4 activity is stimulated by upstream activators and signals, including by HGF, PKD, PKA, CDK5RAP3, and SH3RF2....
fiction in the public domain, including this story at Standard Ebooks Second Variety at Project Gutenberg Second Variety public domain audiobook at LibriVox...
cilium in the renal tubule cells can lead to polycystic kidney disease (PKD). In another genetic disorder called Bardet–Biedl syndrome (BBS), the mutant...
kidney. For example, Pax2 is highly expressed in polycystic kidney disease (PKD), Wilms' tumor (WT), and renal cell carcinoma (RCC). Pax2 expression in these...
Internet Archive An omnibus collection of Dick's short fiction in the public domain, including this story at Standard Ebooks The Hanging Stranger at Project...
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