Group of membrane proteins that passively export cations out of a cell
C-terminal Cytosolic Domain of Polycystin-2
Identifiers
Symbol
PKD2
Pfam
PF08016
InterPro
IPR013122
TCDB
1.A.5
OPM superfamily
8
OPM protein
5mkf
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The Polycystin Cation Channel (PCC) Family (TC# 1.A.5) consists of several transporters ranging in size from 500 to over 4000 amino acyl residues (aas) in length and exhibiting between 5 and 18 transmembrane segments (TMSs). This family is a constituent of the Voltage-Gated Ion Channel (VIC) Superfamily. These transporters generally catalyze the export of cations. A representative list of proteins belonging to the PCC family can be found in the Transporter Classification Database.[1]
^"1.A.5 The Polycystin Cation Channel (PCC) Family". TCDB. Retrieved 10 April 2016.
and 15 Related for: Polycystin cation channel family information
The PolycystinCationChannel (PCC) Family (TC# 1.A.5) consists of several transporters ranging in size from 500 to over 4000 amino acyl residues (aas)...
are molecular sensing, non-selective cationchannels that have six transmembrane segments, however, each sub-family is unique and shares little structural...
in the interaction with the polycystin-1 group. TRPP1 and TRPP3 form constitutively active cation-selective ion channels that are permeable to calcium...
coiled-coil domain through which PC1 interacts with polycystin 2 (PC2), a membrane-bound Ca2+-permeable ion channel. PC1 has been proposed to act as a G protein–coupled...
the sodium channels and are equally large. Cationchannels of sperm: This small family of channels, normally referred to as Catsper channels, is related...
potential cationchannel, mucolipin subfamily) comprises a group of three evolutionarily related proteins that belongs to the large family of transient...
thirst). The channels vary in selectivity for the permeating ions from nonselective between anions and cations in bacteria, to cation selective allowing...
potential Ca2+ channel (TRP-CC) family (TC# 1.A.4) is a member of the voltage-gated ion channel (VIC) superfamily and consists of cationchannels conserved...
formation are tied to abnormal cilia-mediated signaling. The polycystin-1 and polycystin-2 proteins appear to be involved in both autosomal dominant and...
Chen XZ, Vassilev PM, Basora N, et al. (1999). "Polycystin-L is a calcium-regulated cationchannel permeable to calcium ions". Nature. 401 (6751): 383–6...
Zhao W, Chen XZ (2002). "The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation". FEBS Lett. 516 (1–3):...
its large extracellular domains, activating the calcium channels associated with polycystin-2, the product of gene PKD2, as a result of the genetic setting...
Global Information