PFKL information

PFKL
Identifiers
Aliases	PFKL, ATP-PFK, PFK-B, PFK-L, phosphofructokinase, liver type
External IDs	OMIM: 171860 MGI: 97547 HomoloGene: 55668 GeneCards: PFKL
Gene location (Human)
Chr.	Chromosome 21 (human)
End	44,327,376 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	77,845,917 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; skin of abdomen; ; body of stomach; ; canal of the cervix; ; right uterine tube; ; amygdala; ; right lobe of liver; ; nucleus accumbens; ; minor salivary glands; ; gastric mucosa;
	Top expressed in
	brown adipose tissue; ; primitive streak; ; entorhinal cortex; ; somite; ; retinal pigment epithelium; ; pyloric antrum; ; superior frontal gyrus; ; otic placode; ; epithelium of stomach; ; atrium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; monosaccharide binding; metal ion binding; kinase activity; fructose binding; kinase binding; protein binding; catalytic activity; identical protein binding; ATP binding; 6-phosphofructokinase activity; fructose-6-phosphate binding; AMP binding;
Cellular component	cytoplasm; membrane; 6-phosphofructokinase complex; extracellular exosome; cytosol; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	negative regulation of insulin secretion; phosphorylation; canonical glycolysis; protein complex oligomerization; metabolism; glycolytic process through fructose-6-phosphate; protein homotetramerization; glycolytic process; fructose 6-phosphate metabolic process; fructose 1,6-bisphosphate metabolic process; response to glucose; neutrophil degranulation; carbohydrate metabolic process; glucose catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5211
	18641
	ENSG00000141959
	ENSMUSG00000020277
	P17858; Q7L2M7
	P12382
	NM_001002021; NM_002626
	NM_008826; NM_001358793
	NP_001002021; NP_002617; NP_001002021.2; NP_002617.3
	NP_032852; NP_001345722
	Wikidata
View/Edit Human	View/Edit Mouse

6-phosphofructokinase, liver type (PFKL) is an enzyme that in humans is encoded by the PFKL gene on chromosome 21.^[5] This gene encodes the liver (L) isoform of phosphofructokinase-1, an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141959 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020277 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PFKL phosphofructokinase, liver".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141959 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020277 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PFKL phosphofructokinase, liver".

PFKL information

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PFKL

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Tumor hypoxia