Peroxisomal targeting signal 1 receptor (PTS1R) is a protein that in humans is encoded by the PEX5 gene.[5]
PTS1R is a peroxisomal targeting sequence involved in the specific transport of molecules for oxidation inside the peroxisome. SKL binds to PTS1R in the cytosol followed by binding to the Pex14p receptor allowing importation of the peroxisomal protein through the pexsubunit transporter.
Diseases associated with dysfunctional PTS1R receptors include X-linked adrenoleukodystrophy and Zellweger syndrome.
signal 1 receptor (PTS1R) is a protein that in humans is encoded by the PEX5 gene. PTS1R is a peroxisomal targeting sequence involved in the specific...
kinase R (PKR), the major receptor for peroxisomal matrix protein import PEX5, protein arginine methyltransferase 9 (PRMT9), and mitochondrial import proteins...
the peroxisome lumen. The matrix protein import receptors, the peroxins PEX5 and PEX7, accompany their cargoes (containing a PTS1 or a PTS2 amino acid...
is encoded by the PEX5 gene. PEX5 imports folded proteins into the peroxisome, shuttling between the peroxisome and cytosol. PEX5 interacts with a large...
protein called pex5 (peroxin 5). Once bound, pex5 interacts with a peroxisomal membrane protein pex14 to form a complex. When the pex5 protein with bound...
peroxisomes. Most commonly, patients have mutations in the PEX1, PEX2, PEX3, PEX5, PEX6, PEX10, PEX12, PEX13, PEX14, PEX16, PEX19, or PEX26 genes. In almost...
mechanism that shuttles the peroxisome targeting signal receptor protein PEX5 back to the cytosol after release of its protein cargo within the peroxisomal...
complementation groups (CGs). PEX12 has been shown to interact with PEX10, PEX5 and PEX19. GRCh38: Ensembl release 89: ENSG00000108733 – Ensembl, May 2017...
chromosome 2 next to KIAA1841 PEX13 has been shown to interact with PEX14, PEX5 and PEX19. GRCh38: Ensembl release 89: ENSG00000162928 – Ensembl, May 2017...
SCP2 has been shown to interact with Caveolin 1 and peroxisomal receptor PEX5. GRCh38: Ensembl release 89: ENSG00000116171 – Ensembl, May 2017 GRCm38:...
indicates that TMEM267 could be involved in the interaction of Pex14 with Pex5 proteins. Overall, TMEM267 is most likely found in the cytoplasm. The TMEM267...
in one form of Zellweger syndrome. PEX14 has been shown to interact with PEX5, PEX7, and PEX13. GRCh38: Ensembl release 89: ENSG00000142655 – Ensembl,...
verified function of PEX6; PEX6 (and PEX1) removes PEX5 from the peroxisomal membrane so that PEX5 may do additional rounds of peroxisomal import. Human...
motifs and has 16 exons. Other notable TPR containing peptides include HOP, PEX5, and neutrophil cytosolic factor 2. TTC16 is highly conserved among species...
Warren DS, Sacksteder KA, Gould SJ (November 1999). "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein...
Erdmann R (January 2014). "A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes". The Journal of Biological...
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