Global InformationNodular fasciitis information
| Nodular fasciitis | |
|---|---|
| Other names | Nodular pseudosarcomatous fasciitis, subcutaneous pseudosarcomatous fibromatosis |
 | |
| Micrograph of nodular fasciitis showing the haphazard arrangement of cells (tissue culture-like pattern). H&E stain. | |
| Specialty | Rheumatology  |
| Types | Cranial fasciitis, intravascular fasciitis |
Nodular fasciitis (NF) is a benign, soft tissue tumor composed of myofibroblasts that typically occurs in subcutaneous tissue, fascia, and/or muscles.[1][2][3][4] The literature sometimes titles rare NF variants according to their tissue locations. The most frequently used and important of these are cranial fasciitis[5] and intravascular fasciitis.[6] In 2020, the World Health Organization classified nodular fasciitis as in the category of benign fibroblastic/myofibroblastic tumors.[7] NF is the most common of the benign fibroblastic proliferative tumors of soft tissue.[4]
Nodular fasciitis is a rapidly growing, usually self-limiting neoplasm that occurs primarily but not exclusively in adults. Due to its rapid growth, NF is often misdiagnosed as a malignant tumor, usually a sarcoma.[8] Indeed, NF was originally termed subcutaneous pseudosarcomatous fibromatosis when first described in 1955 by Konwaler et al.[9] The correct diagnosis of a tumor as NF is pivotal to prevent its overtreatment as a more aggressive or malignant growth.[8]
While nodular fasciitis may be precipitated by localized injuries, recent studies indicate that NFs are true neoplasms (i.e. abnormal proliferations of cells without any precipitating event). Up to 92% of NF cases have a specific type of fusion gene in their tumor cells which may be responsible for disrupting the regulation of cell growth and death.
- ^ Shields, Jerry A.; Shields, Carol L.; Christian, Colleen; Eagle, Ralph C. (2001-03-01). "Orbital Nodular Fasciitis Simulating a Dermoid Cyst in an 8-Month-Old Child: Case Report and Review of the Literature". Ophthalmic Plastic and Reconstructive Surgery. 17 (2): 144–148. doi:10.1097/00002341-200103000-00015. ISSN 0740-9303. PMID 11281591. S2CID 8577230.
- ^ Skippen, Brent; Tomlinson, Jeanne; Tumuluri, Krishna (2016-01-01). "Periorbital Nodular Fasciitis in Pregnancy: Case Report and Review of the Literature". Ophthalmic Plastic & Reconstructive Surgery. 32 (1): e1–e3. doi:10.1097/IOP.0000000000000408. ISSN 0740-9303. PMID 25689787. S2CID 37939320.
- ^ Anzeljc, Andrew J.; Oliveira, Andre M.; Grossniklaus, Hans E.; Kim, Hee Joon; Hayek, Brent (2017-05-01). "Nodular Fasciitis of the Orbit: A Case Report Confirmed by Molecular Cytogenetic Analysis". Ophthalmic Plastic & Reconstructive Surgery. 33 (3S): S152–S155. doi:10.1097/IOP.0000000000000649. ISSN 0740-9303. PMID 26882059. S2CID 11926695.
- ^ a b Luna A, Molinari L, Bollea Garlatti LA, Ferrario D, Volonteri V, Roitman P, Galimberti G, Mazzuoccolo L (February 2019). "Nodular fasciitis, a forgotten entity". International Journal of Dermatology. 58 (2): 190–193. doi:10.1111/ijd.14219. PMID 30191556. S2CID 52168976.
- ^ Salib C, Edelman M, Lilly J, Fantasia JE, Yancoskie AE (March 2020). "USP6 Gene Rearrangement by FISH Analysis in Cranial Fasciitis: A Report of Three Cases". Head and Neck Pathology. 14 (1): 257–261. doi:10.1007/s12105-019-01018-0. PMC 7021881. PMID 30758758.
- ^ Kim HK, Han A, Ahn S, Min S, Ha J, Min SK (March 2021). "Intravascular Fasciitis in the Femoral Vein with Hypermetabolic Signals Mimicking a Sarcoma: The Role of Preoperative Imaging Studies with Review of Literature". Vascular Specialist International. 37 (1): 50–57. doi:10.5758/vsi.200079. PMC 8021498. PMID 33775935.
- ^ Sbaraglia M, Bellan E, Dei Tos AP (April 2021). "The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives". Pathologica. 113 (2): 70–84. doi:10.32074/1591-951X-213. PMC 8167394. PMID 33179614.
- ^ a b Hiemcke-Jiwa LS, van Gorp JM, Fisher C, Creytens D, van Diest PJ, Flucke U (December 2020). "USP6-Associated Neoplasms: A Rapidly Expanding Family of Lesions". International Journal of Surgical Pathology. 28 (8): 816–825. doi:10.1177/1066896920938878. PMID 32635781. S2CID 220413896.
- ^ KONWALER BE, KEASBEY L, KAPLAN L (March 1955). "Subcutaneous pseudosarcomatous fibromatosis (fasciitis)". American Journal of Clinical Pathology. 25 (3): 241–52. doi:10.1093/ajcp/25.3.241. PMID 14361319.