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Overdominance is a phenomenon in genetics where the phenotype of the heterozygote lies outside the phenotypical range of both homozygous parents. Overdominance can also be described as heterozygote advantage regulated by a single genomic locus, wherein heterozygous individuals have a higher fitness than homozygous individuals. However, not all cases of the heterozygote advantage are considered overdominance, as they may be regulated by multiple genomic regions.[1] Overdominance has been hypothesized as an underlying cause for heterosis (increased fitness of hybrid offspring).[2][3]
Sickle cell anemia overdominance
^Charlesworth, Deborah; Willis, John H. (November 2009). "The genetics of inbreeding depression". Nature Reviews Genetics. 10 (11): 783–796. doi:10.1038/nrg2664. ISSN 1471-0056. PMID 19834483. S2CID 771357.
^Parsons, P. A.; Bodmer, W. F. (April 1961). "The Evolution of Overdominance: Natural Selection and Heterozygote Advantage". Nature. 190 (4770): 7–12. Bibcode:1961Natur.190....7P. doi:10.1038/190007a0. ISSN 0028-0836. PMID 13733020. S2CID 4223238.
^Timberlake, W.E. (2013), "Heterosis", Brenner's Encyclopedia of Genetics, Elsevier, pp. 451–453, doi:10.1016/b978-0-12-374984-0.00705-1, ISBN 978-0-08-096156-9, retrieved 2022-11-04
Overdominance is a phenomenon in genetics where the phenotype of the heterozygote lies outside the phenotypical range of both homozygous parents. Overdominance...
alleles. Dominance and overdominance have different consequences for the gene expression profile of the individuals. If overdominance is the main cause for...
Polar overdominance is a unique form of inheritance originally described in livestock, with relevant examples in humans and mice being discovered shortly...
of heterozygote advantage due to a single locus is known as overdominance. Overdominance is a rare condition in genetics where the phenotype of the heterozygote...
loci) 6. Locus–locus interactions Epistasis with other loci (e.g., overdominance) Gene coupling with other loci (also see crossing over) Homozygotous...
original population. Crossing inbred lines restores fitness in the overdominance hypothesis and a fitness increase in the partial dominance hypothesis...
advantage, heterozygote disadvantage, or negative overdominance," is the opposite of overdominance. It is the selection against the heterozygote, causing...
Peace. In 2004, following the signing of Young Jeezy and hip-hop's overdominance of trap music, the division was folded into Def Jam.[citation needed]...
depression is the fitness advantage of heterozygosity, which is known as overdominance. This can lead to reduced fitness of a population with many homozygous...
can also result in inversion polymorphism by frequency dependence or overdominance. The fitness differences between the inverted and the ancestral chromosome...
angiosperms yet, the environment has a role in it. Dominance versus overdominance Haldane's rule Heterozygote advantage Inbreeding depression This article...
with J. C. King, used the overdominance hypothesis to develop the balance position, which left a larger place for overdominance (where the heterozygous...
outbreeding depression. Segregation load occurs in the presence of overdominance, i.e. when heterozygotes are more fit than either homozygote. In such...
membrane found surrounding the flagella base(s) in some bacteria Polar overdominance a form of genetic mutation All pages with titles containing Polar Polarity...
of heterozygote fitness, heterozygotic advantage may also be called "overdominance" in some literature. A well-studied case is that of sickle cell anemia...
(biology) Operon Organelle Organogenesis Outbreeding Outside markers Overdominance Overlapping clones Ovum P (peptidyl) site P element P1 P53 Palindrome...
hypertrophy. The non-Mendelian inheritance pattern, known as polar overdominance, likely results from the combination of the cis-effect on the expression...
them makes them stronger: an association between elongation factor 1-α overdominance in the sea star Pisaster ochraceus and "sea star wasting disease""....
heterozygote (a situation often referred to as overdominance or heterosis). In the case of overdominance, because Mendel's second law (the law of segregation)...
ISBN 978-0-14-118494-4. OCLC 934630161. James F. Crow (1987). "Muller, Dobzhansky, and Overdominance". Journal of the History of Biology. 20 (3): 351–380. doi:10.1007/bf00139460...
Windsor, Donald; Cáceres, Carla E. (2021-03-11). "A potential role for overdominance in the maintenance of colour variation in the Neotropical tortoise beetle...
fitness than hybrids with only one parental haplotype. This associative overdominance, may slow down the process of fixation of parental alleles through favouring...
function (exaptation). area cladogram asexual reproduction associative overdominance The phenomenon by which the linkage of a neutral locus to a selectively...
for any available allele, which is known as overdominance. Inbreeding depression caused by overdominance cannot be purged, but seems to be a minor cause...
second method through which inbreeding depression occurs is through overdominance, or heterozygote advantage. Individuals that are heterozygous at a particular...
Primates. Alonso, S., López, S., Izagirre, N., & de la Rúa, C. (2008). "Overdominance in the human genome and olfactory receptor activity". Molecular Biology...
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