The overall hemostatic potential (OHP) test is a global coagulation assay which can be used to measure coagulation.[1][2][3][4] The OHP assay measures total fibrin generation in the presence of thrombin or tissue factor and tissue plasminogen activator (t-PA).[2][1][3][4] It generates a fibrin time curve through the use of optical density measurement.[1] This curve represents the balance between fibrin formation induced by thrombin or tissue factor and fibrinolysis induced by t-PA.[1] The assay provides three parameters: overall coagulation potential (OCP), overall hemostatic potential (OHP), and overall fibrinolytic potential (OFP).[2][1][4] OHP is the main parameter, while OCP and OFP are supplementary parameters to assess coagulation and fibrinolysis.[3] One further parameter, clot lysis time (CLT), can also be determined.[3] The OHP assay measures the integrated effect of procoagulant, anticoagulant, and fibrinolytic factors.[1]
The OHP is a technically simple[1][3] but relatively labor-intensive assay.[2] As of 2010, it had been implemented in several laboratories, but was not available commercially.[3] The assay is novel in terms of its combined evaluation of both fibrin generation and fibrinolysis.[1] The test is potentially useful in the evaluation of hypercoagulability, hypocoagulability, and fibrinolytic abnormalities.[1][2][3] It is able to detect hypercoagulability associated with pregnancy and estrogen/progestogen hormone therapy.[3][4] The test has also been used to study coagulation in feminizing hormone therapy in transgender women.[5] However, more studies are needed to validate the test as a biomarker of thrombosis and other abnormalities of coagulation.[2][3][4]
^ abcdefghiCurnow J (2017). "The Overall Hemostatic Potential (OHP) Assay". Hemostasis and Thrombosis. Methods Mol Biol. Vol. 1646. pp. 523–531. doi:10.1007/978-1-4939-7196-1_38. ISBN 978-1-4939-7194-7. PMID 28804852.
^ abcdefLim HY, Donnan G, Nandurkar H, Ho P (January 2022). "Global coagulation assays in hypercoagulable states". J Thromb Thrombolysis. 54 (1): 132–144. doi:10.1007/s11239-021-02621-1. PMID 34997471. S2CID 245804095.
^ abcdefghiAntovic A (October 2010). "The overall hemostasis potential: a laboratory tool for the investigation of global hemostasis". Semin Thromb Hemost. 36 (7): 772–9. doi:10.1055/s-0030-1265294. PMID 20978998. S2CID 35249276.
^ abcdeAntovic A (July 2008). "Screening haemostasis--looking for global assays: the Overall Haemostasis Potential (OHP) method--a possible tool for laboratory investigation of global haemostasis in both hypo- and hypercoagulable conditions". Curr Vasc Pharmacol. 6 (3): 173–85. doi:10.2174/157016108784912028. PMID 18673157.
^Lim HY, Leemaqz SY, Torkamani N, Grossmann M, Zajac JD, Nandurkar H, Ho P, Cheung AS (July 2020). "Global Coagulation Assays in Transgender Women on Oral and Transdermal Estradiol Therapy". J Clin Endocrinol Metab. 105 (7): e2369–e2377. doi:10.1210/clinem/dgaa262. PMID 32413907.
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