Intermediate-magnification micrograph of an osteosarcoma (center and right of image) adjacent to non-malignant bone (left-bottom of image): The top-right of the image has poorly differentiated tumor. Osteoid with a high density of malignant cells is seen between the non-malignant bone and poorly differentiated tumor (H&E stain).
Specialty
Oncology
An osteosarcoma (OS) or osteogenic sarcoma (OGS) (or simply bone cancer) is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and that exhibits osteoblastic differentiation and produces malignant osteoid.[1]
Osteosarcoma is the most common histological form of primary bone sarcoma.[2] It is most prevalent in teenagers and young adults.[3]
^Luetke A, Meyers PA, Lewis A, Juergens H (2014). "Osteosarcoma treatment—where do we stand? A state of the art review". Cancer Treat Rev. 40 (4): 523–532. doi:10.1016/j.ctrv.2013.11.006. PMID 24345772.
^Ottaviani G, Jaffe N (2009). "The Epidemiology of Osteosarcoma". Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research. Vol. 152. New York: Springer. pp. 3–13. doi:10.1007/978-1-4419-0284-9_1. ISBN 978-1-4419-0283-2. PMID 20213383.
^"Osteosarcoma". US National Library of Medicine. PubMed Health. 2013.
An osteosarcoma (OS) or osteogenic sarcoma (OGS) (or simply bone cancer) is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm...
with bone and joint cancer is 67%. The earliest known bone tumor was an osteosarcoma in a foot bone discovered in South Africa, between 1.6 and 1.8 million...
that classify the subtypes of sarcoma. These subtypes are as follows: Osteosarcoma Chondrosarcoma Poorly differentiated round/spindle cell tumors (includes...
on tissue type – an osteosarcoma, a Ewing's sarcoma, and a chondrosarcoma. The three main types of bone sarcoma are an osteosarcoma, most frequently found...
protein 3 (G0S3), is a protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (FOSB) gene. The FOS gene family consists of...
Giulia; Jaffe Norman (2009). "The Epidemiology of Osteosarcoma". Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research. Vol. 152. New York:...
called osteosarcoma, and typically affects middle-age to older dogs of large and giant breeds. Osteosarcoma is less common in cats. Osteosarcoma is an...
functions are especially important when discussing bone cancer, particularly osteosarcoma development, that can be attributed to aberrant cell proliferation control...
Mifamurtide (trade name Mepact, marketed by Takeda) is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults, which...
Area High School (Class of 2013). At age 14, Sobiech was diagnosed with osteosarcoma, a bone cancer that mostly affects children. CBS reported that during...
similar clinical presentations include osteomyelitis, osteosarcoma (especially telangiectatic osteosarcoma), and eosinophilic granuloma. Soft-tissue neoplasms...
of urinary incontinence in female dogs, prostate cancer in males, and osteosarcoma, hemangiosarcoma, cruciate ligament rupture, pyometra, obesity, and diabetes...
leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma. Types of autoimmune diseases it is used for include psoriasis, rheumatoid...
autosomal dominant hereditary disorder. Its name is an initialism of "osteosarcoma, limb anomalies, and erythroid macrocytosis with megaloblastic marrow...
indicates that ADCK1 may have therapeutic implications in diseases such as osteosarcoma and colon cancer. It has been observed to activate the beta-catenin/TCF...
periosteal reaction.[citation needed] The main causes for this sign are osteosarcoma, Ewing's sarcoma, eumycetoma, and a subperiosteal abscess. "Codman's...
case report, it was found to potentially be associated with developing osteosarcoma in test subjects after over two years of use. Adverse effects of teriparatide...
University. His right leg was amputated in 1977 after he was diagnosed with osteosarcoma, though he continued to run using an artificial leg. He also played wheelchair...
at a twofold excess risk to develop osteosarcoma (bone cancer) as compared to intact dogs. The risk of osteosarcoma increases with increasing breed size...
receptor and SNAI2 are found to be involved in the metastastic process of osteosarcoma. While randomized controlled trials have not confirmed that vitamin D...
17-year-old Augustus Waters, an ex-basketball player, amputee, and survivor of osteosarcoma. An American feature film adaptation of the same name as the novel directed...
average have lower levels of these hormones and lower risk of cancer. Osteosarcoma may be promoted by growth hormones. Some treatments and prevention approaches...
bone cancer and osteosarcoma. Series of research concluded that concentration of fluoride in water does not associate with osteosarcoma. The beliefs regarding...
transcription factors that produce these alterations are Delta FBJ murine osteosarcoma viral oncogene homolog B (ΔFosB), cAMP response element binding protein...
was amputated. The post-operative diagnosis was bone cancer—probably osteosarcoma. After a short stay at the family farm in Roche, from 23 July to 23 August...
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