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Mifamurtide information


Mifamurtide
Clinical data
Trade namesMepact
License data
  • EU EMA: by INN
Pregnancy
category
  • not investigated
Routes of
administration		intravenous liposomal infusion over one hour
ATC code
  • L03AX15 (WHO)
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityN/A
Elimination half-lifeminutes (in plasma)
18 hrs (terminal)
Identifiers
IUPAC name
  • 2-[(N-{(2R)-[(2-acetamido-2,3-dideoxy-D-glucopyranos-3-yl)oxy]-propanoyl}-L-alanyl-D-isoglutaminyl-L-alanyl)amino]ethyl (2R)-2,3-bis(hexadecanoyloxy)propyl hydrogen phosphate
CAS Number
  • 83461-56-7 checkY
    838853-48-8 (mifamurtide sodium · x H2O)
PubChem CID
  • 11672602
ChemSpider
  • 9847332 ☒N
UNII
  • EQD2NNX741
KEGG
  • D06619 checkY
Chemical and physical data
FormulaC59H109N6O19P
Molar mass1237.518 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1C(O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O)C(N)=O)OC(=O)CCCCCCCCCCCCCCC
InChI
  • InChI=1S/C59H109N6O19P/c1-7-9-11-13-15-17-19-21-23-25-27-29-31-33-50(69)79-40-46(83-51(70)34-32-30-28-26-24-22-20-18-16-14-12-10-8-2)41-81-85(77,78)80-38-37-61-56(73)42(3)62-49(68)36-35-47(55(60)72)65-57(74)43(4)63-58(75)44(5)82-54-52(64-45(6)67)59(76)84-48(39-66)53(54)71/h42-44,46-48,52-54,59,66,71,76H,7-41H2,1-6H3,(H2,60,72)(H,61,73)(H,62,68)(H,63,75)(H,64,67)(H,65,74)(H,77,78)/t42-,43-,44+,46+,47+,48+,52+,53+,54+,59?/m0/s1 ☒N
  • Key:JMUHBNWAORSSBD-WKYWBUFDSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Mifamurtide (trade name Mepact, marketed by Takeda) is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults, which is lethal in over half of cases. The drug was approved in Europe in March 2009.

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Mifamurtide

Last Update:

Mifamurtide (trade name Mepact, marketed by Takeda) is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults,...

Word Count : 1145

Takeda Oncology

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commercialization of VELCADE in Europe and the rest of the world. MEPACT mifamurtide Mifamurtide is a drug against osteosarcoma, a kind of bone cancer mainly affecting...

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Glycosyl

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is called D-glucopyranos-3-O-yl as it appears in the name of the drug Mifamurtide. Recent detection of the Au3+ in living organism was possible through...

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ATC code L03

Last Update:

L03AX13 Glatiramer acetate L03AX14 Histamine dihydrochloride L03AX15 Mifamurtide L03AX16 Plerixafor L03AX17 Sipuleucel-T L03AX18 Cridanimod L03AX19 Dasiprotimut-T...

Word Count : 353

Osteosarcoma

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tumor recurrence—may cause the need for further surgery or amputation. Mifamurtide is used after a patient has had surgery to remove the tumor and together...

Word Count : 3791

Isoglutamine

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the carboxyl group and isoglutamine behaves as a γ-amino acid, as in mifamurtide, a synthetic derivative of MDP used to treat osteosarcoma. Substituting...

Word Count : 202

Muramyl dipeptide

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pathway in mice that conferred protection from colitis. Taxol Dipeptide Mifamurtide, a synthetic analogue for the treatment of osteosarcoma Inohara N, Ogura...

Word Count : 422

NOD2

Last Update:

report of NOD2 acting as a pattern-recognition receptor for viruses. Mifamurtide, a NOD2 activator for the treatment of osteosarcoma GRCh38: Ensembl release...

Word Count : 1547
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