Osteonecrosis of the jaw of the upper left jaw in a patient diagnosed with chronic venous insufficiency
Specialty
Rheumatology
Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the maxilla and the mandible). Various forms of ONJ have been described since 1861, and a number of causes have been suggested in the literature.
Osteonecrosis of the jaw associated with bisphosphonate therapy, which is required by some cancer treatment regimens, has been identified and defined as a pathological entity (bisphosphonate-associated osteonecrosis of the jaw) since 2003.[1] The possible risk from lower oral doses of bisphosphonates, taken by patients to prevent or treat osteoporosis, remains uncertain.[2]
Treatment options have been explored; however, severe cases of ONJ still require surgical removal of the affected bone.[3] A thorough history and assessment of pre-existing systemic problems and possible sites of dental infection are required to help prevent the condition, especially if bisphosphonate therapy is considered.[2]
^Alexandru Bucur, Tiberiu Niță, Octavian Dincă, Cristian Vlădan, Mihai Bogdan Bucur (November 2011). "Bisphosphonate associated osteonecrosis of the jaw". Rev. chir. oro-maxilo-fac. implantol. (in Romanian). 2 (3): 24–27. ISSN 2069-3850. 43. Retrieved 6 June 2012.{{cite journal}}: CS1 maint: multiple names: authors list (link)(webpage has a translation button)
^ abWoo S; Hellstein J; Kalmar J (2006). "Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws". Ann Intern Med. 144 (10): 753–61. doi:10.7326/0003-4819-144-10-200605160-00009. PMID 16702591. S2CID 53091343.
^Bouquot JE; Christian J (1995). "Long-term effects of jawbone curettage on the pain of facial neuralgia". J. Oral Maxillofac. Surg. 53 (4): 387–97, discussion 397–9. doi:10.1016/0278-2391(95)90708-4. PMID 7699492.
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