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Pamidronic acid information


Pamidronic acid
Clinical data
Trade namesAredia, Pamimed, among others
Other namesPamidronate disodium pentahydrate, pamidronate disodium
AHFS/Drugs.comInternational Drug Names
MedlinePlusa601163
Pregnancy
category
  • AU: B3
Routes of
administration		Intravenous
ATC code
  • M05BA03 (WHO)
Legal status
Legal status
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailabilityn/a
Protein binding54%
MetabolismNil
Elimination half-life28 ± 7 hours
ExcretionRenal
Identifiers
IUPAC name
  • (3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)
CAS Number
  • 40391-99-9 checkY
PubChem CID
  • 4674
IUPHAR/BPS
  • 7259
DrugBank
  • DB00282 checkY
ChemSpider
  • 4512 checkY
UNII
  • OYY3447OMC
KEGG
  • D07281 checkY
ChEMBL
  • ChEMBL834 checkY
CompTox Dashboard (EPA)
  • DTXSID4023414 Edit this at Wikidata
ECHA InfoCard100.049.897 Edit this at Wikidata
Chemical and physical data
FormulaC3H11NO7P2
Molar mass235.069 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=P(O)(O)C(O)(CCN)P(=O)(O)O
InChI
  • InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11) checkY
  • Key:WRUUGTRCQOWXEG-UHFFFAOYSA-N checkY
  (verify)

Pamidronic acid or pamidronate disodium or APD (marketed as Aredia among others), is a nitrogen-containing bisphosphonate used to prevent osteoporosis.

It was patented in 1971 and approved for medical use in 1987.[1]

  1. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 523. ISBN 9783527607495.

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Pamidronic acid

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Pamidronic acid or pamidronate disodium or APD (marketed as Aredia among others), is a nitrogen-containing bisphosphonate used to prevent osteoporosis...

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APD

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may refer to: Afferent pupillary defect Acid Peptic Diseases Ambulatory Peritoneal Dialysis Pamidronic acid, also known as aminohydroxypropylidene bisphosphonate...

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ATC code M05

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acid M05BA02 Clodronic acid M05BA03 Pamidronic acid M05BA04 Alendronic acid M05BA05 Tiludronic acid M05BA06 Ibandronic acid M05BA07 Risedronic acid M05BA08...

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Steroidogenesis inhibitor

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conversion of HMG-CoATooltip 3-hydroxy-3-methylglutaryl-coenzyme A into mevalonic acid, a relatively early step in the biosynthesis of cholesterol from acetyl coenzyme...

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Molecular graphics

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 267–274. Corey, Robert B.; Pauling, Linus (1953). "Molecular Models of Amino Acids, Peptides, and Proteins". Review of Scientific Instruments. 24 (8): 621...

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