Alendronic acid information

Alendronic acid
Clinical data
Trade names	Fosamax, Binosto, others
Other names	Alendronate, alendronate sodium (USAN US)
AHFS/Drugs.com	Monograph
MedlinePlus	a601011
License data	US DailyMed: Alendronate sodium;
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth
ATC code	M05BA04 (WHO) ;
Legal status
Legal status	CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	0.6%
Metabolism	excreted unchanged
Elimination half-life	126 months
Excretion	Kidney
Identifiers
	IUPAC name sodium [4-amino-1-hydroxy-1-(hydroxy-oxido-phosphoryl)- butyl]phosphonic acid trihydrate;
CAS Number	66376-36-1 ; Sodium salt: 121268-17-5 ;
PubChem CID	2088;
IUPHAR/BPS	3141;
DrugBank	DB00630 ;
ChemSpider	2004 ;
UNII	X1J18R4W8P; Sodium salt: 2UY4M2U3RA ;
KEGG	D07119 ; Sodium salt: D00939 ;
ChEBI	CHEBI:2567 ;
ChEMBL	ChEMBL870 ;
CompTox Dashboard (EPA)	DTXSID5022568 ;
ECHA InfoCard	100.128.415
Chemical and physical data
Formula	C4H13NO7P2
Molar mass	249.096 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=P(O)(O)C(O)(CCCN)P(=O)(O)O;
	InChI InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12) ; Key:OGSPWJRAVKPPFI-UHFFFAOYSA-N ;
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Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone.^[3] It is taken by mouth.^[3] Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes.^[3]

Common side effects (1 to 10% of patients) include constipation, abdominal pain, nausea, and acid reflux.^[3] Use is not recommended during pregnancy or in those with poor kidney function.^[4] Alendronic acid works by decreasing the activity of cells that break down bone.^[3]

Alendronic acid was first described in 1978 and approved for medical use in the United States in 1995.^[3]^[5] It is available as a generic medication. In 2021, it was the 94th most commonly prescribed medication in the United States, with more than 7 million prescriptions.^[6]^[7]

^ "Alendronate Use During Pregnancy". Drugs.com. 22 August 2019. Retrieved 17 May 2020.
^ "Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 3 April 2024.
^ ^a ^b ^c ^d ^e ^f "Fosamax Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 2 February 2019.
^ British National Formulary : BNF 76 (76 ed.). Pharmaceutical Pres s. 2018. pp. 710–711. ISBN 978-0-85711-338-2.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 523. ISBN 978-3-527-60749-5.
^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^ "Alendronate - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

[Drugs.com_pregnancy-1] "Alendronate Use During Pregnancy". Drugs.com. 22 August 2019. Retrieved 17 May 2020.

[2] "Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 3 April 2024.

[AHFS2019-3] ^ ^a ^b ^c ^d ^e ^f "Fosamax Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 2 February 2019.

[BNF76-4] British National Formulary : BNF 76 (76 ed.). Pharmaceutical Pres s. 2018. pp. 710–711. ISBN 978-0-85711-338-2.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 523. ISBN 978-3-527-60749-5.

[6] "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.

[7] "Alendronate - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

Alendronic acid information

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